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Izquierdo (Spanish pronunciation: [iθˈkjeɾðo, is-]; Spanish for "left") is a Spanish surname. Notable people with the surname include:

• Calixto Garcia de Luna e Izquierdo, merchant born in Soria, Castilla c. 1768
• Elisa Izquierdo (1989–1995), six-year-old girl from the US, beaten to death by her mother
• Hank Izquierdo (1931–2015), Cuban Major League Baseball player
• Hansel Izquierdo (born 1977), retired Major League Baseball pitcher
• Ivan Izquierdo, Argentine Brazilian scientist and neurobiologist
• José Heriberto Izquierdo Mena (born 1992), Colombian footballer
• José Izquierdo (footballer born 1980) (born 1980), Spanish footballer
• Jose Izquierdo Encarnacion 19th Secretary of State of the Commonwealth of Puerto Rico
• J. P. Izquierdo (born 1969), Canadian football player
• Julio Izquierdo Labrado (born 1958), Spanish writer and doctor of history
• Lilia Izquierdo (born 1967), former female volleyball player from Cuba, thrice Olympic gold medallist
• Manuel Izquierdo (1928–2009), sculptor and woodcut artist
• María Izquierdo (artist) (1902–1955), Mexican painter
• María Izquierdo (actress) (born 1960), Chilean actress
• María Izquierdo Rojo (born 1946), Spanish politician
• Miguel Ramón Izquierdo (1919–2007), Spanish politician, mayor of Valencia
• Rafael de Izquierdo y Gutiérrez, Spanish Military Officer, became Governor-General of the Philippines 1871–1873
• Vicente Guillén Izquierdo (born 1958), Spanish politician who belongs to the governing PSOE