JWH-367
Legal status
Legal status
Identifiers
  • [5-(3-methoxyphenyl)-1-pentylpyrrol-3-yl]-naphthalen-1-ylmethanone
CAS Number
  • 914458-30-3 checkY
PubChem CID
ChemSpider
Chemical and physical data
FormulaC27H27NO2
Molar mass397.518 g·mol−1
3D model (JSmol)
  • CCCCCN1C=C(C=C1C2=CC(=CC=C2)OC)C(=O)C3=CC=CC4=CC=CC=C43
  • InChI=1S/C27H27NO2/c1-3-4-7-16-28-19-22(18-26(28)21-12-8-13-23(17-21)30-2)27(29)25-15-9-11-20-10-5-6-14-24(20)25/h5-6,8-15,17-19H,3-4,7,16H2,1-2H3 checkY
  • Key:RGYBGMOZXHKLRI-UHFFFAOYSA-N checkY

JWH-367 ([5-(3-methoxyphenyl)-1-pentylpyrrol-3-yl]-naphthalen-1-ylmethanone) is a synthetic cannabinoid from the naphthoylpyrrole family which acts as an agonist of the CB1 (Ki = 53 ± 2nM) and CB2 (Ki = 23 ± 1nM) receptors, binding ~2.3 times stronger to the CB2 receptor than to the CB1 receptor. JWH-367 was first synthesized in 2006 by John W. Huffman and colleagues to examine the nature of ligand binding to the CB1 receptor.[1]

Legality

In the United States JWH-367 is not federally scheduled, although some states have passed legislation banning the sale, possession, and manufacture of JWH-367.[2][3][4][5]

In Canada, JWH-367 and other naphthoylpyrrole-based cannabinoids are Schedule II controlled substances under the Controlled Drugs and Substances Act.

In the United Kingdom, JWH-367 and other naphthoylpyrrole-based cannabinoids are considered Class B drugs under the Misuse of Drugs Act 1971.

See also

References

  1. ^ Huffman JW, Padgett LW, Isherwood ML, Wiley JL, Martin BR (October 2006). "1-Alkyl-2-aryl-4-(1-naphthoyl)pyrroles: new high affinity ligands for the cannabinoid CB1 and CB2 receptors". Bioorganic & Medicinal Chemistry Letters. 16 (20): 5432–5. doi:10.1016/j.bmcl.2006.07.051. PMID 16889960.
  2. ^ 21 U.S.C. § 812: Schedules of controlled substances
  3. ^ "The 2020 Florida Statutes". www.leg.state.fl.us. Retrieved 20 August 2021.
  4. ^ "Arizona Revised Statutes Title 13. Criminal Code § 13-3401". www.azleg.gov. Retrieved 20 August 2021.
  5. ^ "California Code, Health and Safety Code - HSC § 11357.5". Findlaw.