James Haber
Born
James E. Haber

1943[1]
Pittsburgh, Pennsylvania[1]
EducationHarvard University, AB; University of California, Berkeley, Ph.D. 1970
Known forDNA repair mechanisms
AwardsNational Academy of Sciences, American Association for the Advancement of Science, Thomas Hunt Morgan Medal of the Genetics Society of America
Scientific career
FieldsBiochemistry, Genetics
InstitutionsUniversity of Wisconsin, Brandeis University
Academic advisorsDaniel E. Koshland, Jr.

James E. Haber is an American molecular biologist known for discoveries in the field of DNA repair, in particular for his contributions to understanding the mechanisms of non-homologous end joining and microhomology-mediated end joining, as well as homologous recombination.[1]

Early life

Haber was born in Pittsburgh, Pennsylvania in 1943.[1]

Education

Haber obtained his AB at Harvard University, and his Ph.D. at the University of California, Berkeley, under the supervision of Daniel E. Koshland, Jr., working at that time on subunit interactions in proteins such as hemoglobin,[2][3] as well as more general aspects of protein structure.[4] After obtaining his doctorate he moved to the Laboratory of Molecular Biology, University of Wisconsin, Madison, Wisconsin for post-doctoral work in the group of Harlyn Halvorson, when he studied the cell cycle dependence of sporulation in yeast.[5]

Career at Brandeis University

After his postdoctoral research Haber moved to Brandeis University, where he became the Abraham and Etta Goodman Professor of Biology, and Director of the Rosenstiel Basic Medical Sciences Research Center, and where he has spent his career. There he studied various aspects of DNA repair,[6][7] including mechanisms of non-homologous end-joining in yeast.[8] He has also worked on histone chaperones and the regulation of histone traffic.[9]

Distinctions

Haber was elected to the National Academy of Sciences in 2010.[1] In 2011 he received the Thomas Hunt Morgan Medal of the Genetics Society of America. He is a Fellow of the American Association for the Advancement of Science, the American Academy of Microbiology and the American Academy of Arts and Sciences.

References

  1. ^ a b c d e "James Haber". www.nasonline.org.
  2. ^ Haber, J. E.; Koshland, D. E., Jr. (1967). "Relation of protein subunit interactions to the molecular species observed during cooperative binding of ligands". Proc. Natl. Acad. Sci. USA. 58 (5): 2087–2093. Bibcode:1967PNAS...58.2087H. doi:10.1073/pnas.58.5.2087. PMC 223909. PMID 5237502.((cite journal)): CS1 maint: multiple names: authors list (link)
  3. ^ Haber, J. E.; Koshland, D. E., Jr. (1969). "Evidence for β-β interactions during the binding of oxygen to hemoglobin". Biochim. Biophys. Acta. 194 (1): 339–341. doi:10.1016/0005-2795(69)90215-3. PMID 5353133.((cite journal)): CS1 maint: multiple names: authors list (link)
  4. ^ Haber, J. E.; Koshland, D. E., Jr. (1970). "An evaluation of the relatedness of proteins based on comparison of amino acid sequences". J. Mol. Biol. 50 (3): 617–639. doi:10.1016/0022-2836(70)90089-6. PMID 4097749.((cite journal)): CS1 maint: multiple names: authors list (link)
  5. ^ Haber, J. E.; Halvorson, H.O. (1972). "Cell cycle dependency of sporulation in Saccharomyces cerevisiae'". J. Bacteriol. 109 (3): 1027–1033. doi:10.1128/JB.109.3.1027-1033.1972. PMC 247323. PMID 4551739.
  6. ^ Haber, J. E. (2000). "Partners and pathways: Repairing a double-strand break". Trends Genet. 16 (6): 259–264. doi:10.1016/S0168-9525(00)02022-9. PMID 10827453.
  7. ^ Harrison, J. C.; Haber, J. E. (2006). "Surviving the breakup: The DNA damage checkpoint". Annu. Rev. Genet. 40: 209–235. doi:10.1146/annurev.genet.40.051206.105231. PMID 16805667.
  8. ^ Moore, J. K.; Haber, J. E. (1996). "Cell cycle and genetic requirements of two pathways of nonhomologous end-joining repair of double-strand breaks in Saccharomyces cerevisiae". Mol. Cell. Biol. 16 (5): 2164–2173. doi:10.1128/mcb.16.5.2164. PMC 231204. PMID 8628283.
  9. ^ De Koning, L.; Corpet, A.; Haber, J. E.; Almouzni, G. (2007). "Histone chaperones: an escort network regulating histone traffic". Nat. Struct. Mol. Biol. 14 (11): 997–1007. doi:10.1038/nsmb1318. PMID 17984962. S2CID 38172713.

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