John Griffin may refer to:

Lawyers

• John Griffin (judge) (1774/1779 – after 1823), American jurist and member of the Michigan Territorial Supreme Court, 1806–1823
• John Bowes Griffin (1903–1992), British lawyer, Chief Justice of Uganda and first Speaker of the Ugandan Parliament

Politicians

• John Griffin (Allegany County, New York) (c. 1771–1846), New York politician
• John Griffin (MP) (fl. 1414), English politician
• John Gardner Griffin (1815–?), Wisconsin and Connecticut politician
• John K. Griffin (1789–1841), U.S. Congressman from South Carolina, 1831–1841
• John Strother Griffin (1816–1898), American surgeon and politician in Los Angeles
• John W. Griffin (politician) (1927–2006), American local political figure in Ohio

Sports personalities

• John Griffin (alpine skier) (1930–2005), Canadian alpine skier
• John Griffin (baseball) (1913–1984), American baseball player
• John Griffin (basketball) (born 1956), American college basketball player and coach
• John Griffin (defensive back) (born 1939), American football defensive back
• John Griffin (hurler) (born 1984), Irish hurler with the Kerry hurling team
• John Griffin (rugby league) (fl. 1970s–1980s), New Zealand rugby player
• John Griffin (rugby union) (1859–1895), English doctor who played international rugby for Wales
• John Griffin (running back) (born 1988), American football player
• John-Ford Griffin (born 1979), American Major League Baseball outfielder
• John Griffin III, American college basketball coach
• Corn Griffin (John Charles Griffin, 1911–1973), American boxer

Others

• John Griffin, 4th Baron Howard de Walden (1719–1797), English nobleman and army officer
• John Howard Griffin (1920–1980), American journalist and novelist
• John Joseph Griffin (1802–1877), English chemist and publisher
• John Smith Griffin (1807–1899), American missionary in Oregon Country
• John W. Griffin (archaeologist) (1919–1993), American historian in Florida
• Johnny Griffin (1928–2008), American bop and hard bop tenor saxophonist
• John Griffin (businessman) (born 1942), British businessman and philanthropist
• John H. Griffin (1914–1988), Deputy Supreme Knight of the Knights of Columbus