John Kane may refer to:

Entertainment

• John Kane (actor) (1746–1799), Irish actor and comedian
• John Kane (artist) (1860–1934), Scottish-born American painter
• John Kane (writer) (born 1945), British actor and writer

Law

• John L. Kane Jr. (born 1937), U.S. federal judge
• M. John Kane IV, Oklahoma Supreme Court Justice

Military

• John Kane (Medal of Honor), American soldier who fought in the American Civil War
• John R. Kane (1907–1996), American aviator and Medal of Honor recipient

Politics

• John I. Kane, American politician, Pennsylvania State Senator, and trade unionist
• John K. Kane (1795–1858), American politician
• John Kane (trade unionist) (1819–1876), British trade unionist
• Jock Kane (John Kane, 1921–2013), British intelligence agency officer and GCHQ whistleblower
• John Kane (politician), American politician, Oklahoma State House Representative

Sports

• John Kane (outfielder) (1882–1934), American baseball outfielder for the Cubs and Reds
• John Kane (infielder) (1900–1956), American baseball infielder for the Chicago White Sox
• John Kane (footballer, born 1960), English football player
• John Kane (footballer, born 1987), Scottish football player

Other

• John M. Kane, American psychiatrist
• John Innes Kane, American explorer, scientist and philanthropist