KCNK6
Identifiers
Aliases	KCNK6, K2p6.1, KCNK8, TOSS, TWIK-2, TWIK2, potassium two pore domain channel subfamily K member 6
External IDs	OMIM: 603939 MGI: 1891291 HomoloGene: 31266 GeneCards: KCNK6
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.2 Start 38,319,845 bp[1] End 38,332,076 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 B1|7 16.94 cM Start 28,921,351 bp[2] End 28,931,940 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte right coronary artery ascending aorta myometrium vagina smooth muscle tissue parotid gland left coronary artery skin of abdomen cavity of mouth Top expressed in fossa skin of abdomen right lobe of liver epithelium of stomach Paneth cell parotid gland condyle belly cord calvaria left colon More reference expression data BioGPS More reference expression data
Gene ontology Molecular function inward rectifier potassium channel activity voltage-gated ion channel activity potassium channel activity potassium ion leak channel activity Cellular component integral component of membrane voltage-gated potassium channel complex plasma membrane membrane integral component of plasma membrane Biological process regulation of resting membrane potential potassium ion transport regulation of ion transmembrane transport cardiac conduction ion transport negative regulation of systemic arterial blood pressure potassium ion transmembrane transport regulation of systemic arterial blood pressure stabilization of membrane potential Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9424 52150 Ensembl ENSG00000099337 ENSMUSG00000046410 UniProt Q9Y257 n/a RefSeq (mRNA) NM_004823 NM_001033525 RefSeq (protein) NP_004814 NP_004814.1 n/a Location (UCSC) Chr 19: 38.32 – 38.33 Mb Chr 7: 28.92 – 28.93 Mb PubMed search [3] [4]
Wikidata
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Potassium channel subfamily K member 6 is a protein that in humans is encoded by the KCNK6 gene.^[5][6][7][8]

This gene encodes K_2P6.1, one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. K_2P6.1, considered an open rectifier, is widely expressed. It is stimulated by arachidonic acid, and inhibited by internal acidification and volatile anaesthetics.^[8]