KCNMB2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1JO6
Identifiers
Aliases	KCNMB2, potassium calcium-activated channel subfamily M regulatory beta subunit 2
External IDs	OMIM: 605214 MGI: 1919663 HomoloGene: 4257 GeneCards: KCNMB2
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q26.32 Start 178,272,932 bp[1] End 178,844,429 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 A3 Start 31,956,656 bp[2] End 32,254,329 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in islet of Langerhans right uterine tube bronchial epithelial cell caput epididymis corpus epididymis cingulate gyrus prefrontal cortex Brodmann area 23 Brodmann area 9 smooth muscle tissue Top expressed in trigeminal ganglion islet of Langerhans olfactory epithelium superior cervical ganglion secondary oocyte carotid body neural tube pituitary gland substantia nigra lateral geniculate nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function potassium channel regulator activity calcium-activated potassium channel activity ion channel inhibitor activity Cellular component integral component of membrane voltage-gated potassium channel complex plasma membrane integral component of plasma membrane membrane Biological process detection of calcium ion action potential potassium ion transport regulation of vasoconstriction ion transport neuronal action potential chemical synaptic transmission potassium ion transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10242 72413 Ensembl ENSG00000197584 ENSMUSG00000037610 UniProt Q9Y691 Q9CZM9 RefSeq (mRNA) NM_001278911 NM_005832 NM_181361 NM_028231 RefSeq (protein) NP_001265840 NP_005823 NP_852006 NP_082507 Location (UCSC) Chr 3: 178.27 – 178.84 Mb Chr 3: 31.96 – 32.25 Mb PubMed search [3] [4]
Wikidata
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KCNMB2, ball and chain domain
solution structure of the cytoplasmic n-terminus of the bk beta-subunit kcnmb2
Identifiers
Symbol	KcnmB2_inactiv
Pfam	PF09303
InterPro	IPR015382
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

Calcium-activated potassium channel subunit beta-2 is a protein that in humans is encoded by the KCNMB2 gene.^[5][6]

Big Potassium (BK) channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. BK channels can contain two distinct subunits: a pore-forming alpha subunit and a modulatory beta subunit. Each complete BK channel contains four copies of the pore-forming alpha subunit and up to four beta subunits. The protein encoded by the KCNMB2 gene is an auxiliary beta subunit which influences the calcium sensitivity of BK currents and, following activation of BK current, causes persistent inactivation. The subunit encoded by the KCNMB2 gene is expressed in various endocrine cells, including pancreas and adrenal chromaffin cells. It is also found in the brain, including the hippocampus. The KCNMB2 gene is homologous to three other genes found in mammalian genomes: KCNMB1 (found primarily in smooth muscle), KCNMB3, and KCNMB4 (the primary brain BK auxiliary subunit).^[6]

Calcium-activated potassium channel subunit beta-2 comprises two domains. An N-terminal cytoplasmic domain, the ball and chain domain, which is responsible for the fast inactivation of these channels,^[7] and a C-terminal calcium-activated potassium channel beta subunit domain. The N-terminal domain only occurs in calcium-activated potassium channel subunit beta-2, while the C-terminal domain is found in related proteins.