KIF18A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3LRE
Identifiers
Aliases	KIF18A, MS-PPP1R99, kinesin family member 18A
External IDs	OMIM: 611271 MGI: 2446977 HomoloGene: 41820 GeneCards: KIF18A
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p14.1 Start 28,020,619 bp[1] End 28,108,156 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 E3 Start 109,111,083 bp[2] End 109,172,092 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte ganglionic eminence sperm testicle stromal cell of endometrium bone marrow spongy bone rectum bone marrow cells lymph node Top expressed in secondary oocyte spermatid spermatocyte medial ganglionic eminence otic placode maxillary prominence abdominal wall morula primitive streak somite More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding microtubule motor activity tubulin-dependent ATPase activity microtubule binding microtubule plus-end binding protein binding actin binding plus-end-directed microtubule motor activity ATP binding ATPase activity Cellular component cytoplasm cytosol cell projection kinetochore microtubule kinesin complex ruffle microtubule cytoskeleton microtubule organizing center mitotic spindle midzone caveola microtubule cytoskeleton nucleus kinetochore mitotic spindle astral microtubule Biological process antigen processing and presentation of exogenous peptide antigen via MHC class II male meiotic nuclear division regulation of microtubule cytoskeleton organization microtubule-based movement seminiferous tubule development protein transport microtubule depolymerization mitotic metaphase plate congression retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum cellular response to estradiol stimulus mitotic sister chromatid segregation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 81930 228421 Ensembl ENSG00000121621 ENSMUSG00000027115 UniProt Q8NI77 Q91WD7 RefSeq (mRNA) NM_031217 NM_139303 RefSeq (protein) NP_112494 NP_647464 Location (UCSC) Chr 11: 28.02 – 28.11 Mb Chr 2: 109.11 – 109.17 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Kinesin family member KIF18A is a human protein encoded by the KIF18A gene.^[5][6] It is part of the kinesin family of motor proteins.

Function

KIF18A is a plus-end directed motor protein, and migrates to the plus ends of the spindle during early mitosis. It first accumulates there during prophase and metaphase, and is depleted during anaphase.^[7]