KIF3A
Identifiers
AliasesKIF3A, FLA10, KLP-20, kinesin family member 3A
External IDsOMIM: 604683 MGI: 107689 HomoloGene: 38266 GeneCards: KIF3A
Orthologs
SpeciesHumanMouse
Entrez

11127

16568

Ensembl

ENSG00000131437

ENSMUSG00000018395

UniProt

Q9Y496

P28741

RefSeq (mRNA)

NM_001300791
NM_001300792
NM_007054

NM_001290805
NM_001290806
NM_008443

RefSeq (protein)

NP_001287720
NP_001287721
NP_008985

NP_001277734
NP_001277735
NP_032469

Location (UCSC)Chr 5: 132.69 – 132.74 MbChr 11: 53.46 – 53.49 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Kinesin-like protein KIF3A is a protein that in humans is encoded by the KIF3A gene.[5][6]

Function

KIF3A is one subunit of the heterotrimeric motor protein, kinesin-2, that was initially isolated from sea urchin egg/embryo cytosol using microtubule affinity purification.[7] This motor consists of two kinesin-related subunits (called KIF3A and KIF3B or 3C in vertebrates) and an associated protein (KAP3), and it transports protein complexes, nucleic acids and organelles towards the "plus" ends of microtubule tracks within cells. Work done in a broad range of eukaryotic cells has revealed that heterotrimeric kinesin-2 is the primary motor protein driving the intraflagellar transport of tubulins and other axonemal building blocks from the base of the ciliary/flagellar axoneme to their site of assembly at the distal tips.[8] This process is required for cilium assembly/maintenance and cilium-based signalling which play key roles in various cell and developmental processes. For example, in vertebrate embryos, kinesin-2 function is required for cilia-dependent nodal flow and the development of left-right asymmetry.[9]

Interactions

KIF3A has been shown to interact with MAP3K10.[10]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000131437 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000018395 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Whitehead JL, Wang SY, Bost-Usinger L, Hoang E, Frazer KA, Burnside B (November 1999). "Photoreceptor localization of the KIF3A and KIF3B subunits of the heterotrimeric microtubule motor kinesin II in vertebrate retina". Exp. Eye Res. 69 (5): 491–503. doi:10.1006/exer.1999.0724. PMID 10548469.
  6. ^ "Entrez Gene: KIF3A kinesin family member 3A".
  7. ^ Cole DG, Chinn SW, Wedaman KP, Hall K, Vuong T, Scholey JM (November 1993). "Novel heterotrimeric kinesin-related protein purified from sea urchin eggs". Nature. 366 (6452): 268–70. Bibcode:1993Natur.366..268C. doi:10.1038/366268a0. PMID 8232586. S2CID 4367715.
  8. ^ Rosenbaum JL, Witman GB (November 2002). "Intraflagellar transport". Nat. Rev. Mol. Cell Biol. 3 (11): 813–25. doi:10.1038/nrm952. PMID 12415299. S2CID 12130216.
  9. ^ Nonaka S, Tanaka Y, Okada Y, Takeda S, Harada A, Kanai Y, Kido M, Hirokawa N (December 1998). "Randomization of left-right asymmetry due to loss of nodal cilia generating leftward flow of extraembryonic fluid in mice lacking KIF3B motor protein". Cell. 95 (6): 829–37. doi:10.1016/S0092-8674(00)81705-5. PMID 9865700. S2CID 62805329.
  10. ^ Nagata K, Puls A, Futter C, Aspenstrom P, Schaefer E, Nakata T, Hirokawa N, Hall A (January 1998). "The MAP kinase kinase kinase MLK2 co-localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3". EMBO J. 17 (1): 149–58. doi:10.1093/emboj/17.1.149. PMC 1170366. PMID 9427749.

Further reading

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