KIR2DL4
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 3WYR
Identifiers
Aliases	KIR2DL4, CD158D, G9P, KIR-103AS, KIR103, KIR103AS, KIR, KIR-2DL4, killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4
External IDs	OMIM: 604945 HomoloGene: 124412 GeneCards: KIR2DL4
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.42 Start 54,803,611 bp[1] End 54,814,517 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in spleen blood right lung rectum duodenum appendix upper lobe of left lung gallbladder lymph node monocyte n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding transmembrane signaling receptor activity MHC class Ib receptor activity Cellular component integral component of membrane plasma membrane integral component of plasma membrane membrane endosome early endosome membrane Biological process cellular defense response signal transduction regulation of immune response positive regulation of natural killer cell cytokine production negative regulation of natural killer cell mediated cytotoxicity positive regulation of cellular senescence Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3805 n/a Ensembl ENSG00000274945 ENSG00000278606 ENSG00000277540 ENSG00000273575 ENSG00000275732 ENSG00000275699 ENSG00000275317 ENSG00000284509 ENSG00000277750 ENSG00000284365 ENSG00000275848 ENSG00000275456 ENSG00000274955 ENSG00000277964 ENSG00000277362 ENSG00000276979 ENSG00000283961 ENSG00000277850 ENSG00000284460 ENSG00000278074 ENSG00000277076 ENSG00000274189 ENSG00000276044 ENSG00000276779 ENSG00000277355 ENSG00000283869 ENSG00000278201 ENSG00000278271 ENSG00000275237 ENSG00000189013 ENSG00000273498 ENSG00000274193 ENSG00000278430 ENSG00000274232 ENSG00000274609 ENSG00000284013 ENSG00000283986 ENSG00000284340 ENSG00000284562 ENSG00000284206 ENSG00000284457 n/a UniProt Q99706 n/a RefSeq (mRNA) NM_002255 NM_001080770 NM_001080772 NM_001258383 n/a RefSeq (protein) NP_001074239 NP_001074241 NP_002246 n/a Location (UCSC) Chr 19: 54.8 – 54.81 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Killer cell immunoglobulin-like receptor 2DL4 is a protein that in humans is encoded by the KIR2DL4 gene.^[3][4]

Function

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of CD8+ T cells.^[5] The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR2DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the "framework" loci that is present on all haplotypes. Alternative splicing results in multiple transcript variants.^[4]

The only so far reported ligand of KIR2DL4 is the non-classical HLA class 1 gene HLA-G, leading to the inhibition of the cytolytic NK cell function.^[5]