KLK1
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1SPJ
Identifiers
Aliases	KLK1, KLKR, Klk6, hK1, kallikrein 1
External IDs	OMIM: 147910 HomoloGene: 110727 GeneCards: KLK1
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.33 Start 50,819,146 bp[1] End 50,823,787 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas parotid gland rectum skin of abdomen islet of Langerhans kidney minor salivary gland spleen kidney tubule duodenum n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptidase activity serine-type peptidase activity serine-type endopeptidase activity hydrolase activity Cellular component extracellular exosome nucleus secretory granule Biological process proteolysis regulation of systemic arterial blood pressure zymogen activation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3816 n/a Ensembl ENSG00000167748 n/a UniProt P06870 n/a RefSeq (mRNA) NM_002257 n/a RefSeq (protein) NP_002248 n/a Location (UCSC) Chr 19: 50.82 – 50.82 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Kallikrein-1 is a protein that in humans is encoded by the KLK1 gene.^[3][4][5] KLK1 is a member of the peptidase S1 family.

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. This protein is functionally conserved in its capacity to release the vasoactive peptide, Lys-bradykinin, from low molecular weight kininogen.^[6]