KLK12
Identifiers
AliasesKLK12, KLK-L5, KLKL5, kallikrein related peptidase 12
External IDsOMIM: 605539 MGI: 1916761 HomoloGene: 44690 GeneCards: KLK12
Orthologs
SpeciesHumanMouse
Entrez

43849

69511

Ensembl

ENSG00000186474

ENSMUSG00000044430

UniProt

Q9UKR0

B2RVZ0

RefSeq (mRNA)

NM_027097

RefSeq (protein)

NP_081373

Location (UCSC)Chr 19: 51.03 – 51.04 MbChr 7: 43.42 – 43.42 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Kallikrein-12 is a protein that in humans is encoded by the KLK12 gene.[5][6][7]

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing of this gene results in three transcript variants encoding different isoforms.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000186474 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000044430 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Lundwall A, Band V, Blaber M, Clements JA, Courty Y, Diamandis EP, Fritz H, Lilja H, Malm J, Maltais LJ, Olsson AY, Petraki C, Scorilas A, Sotiropoulou G, Stenman UH, Stephan C, Talieri M, Yousef GM (Jun 2006). "A comprehensive nomenclature for serine proteases with homology to tissue kallikreins". Biol Chem. 387 (6): 637–41. doi:10.1515/BC.2006.082. PMID 16800724. S2CID 436200.
  6. ^ Diamandis, Eleftherios P.; Deperthes, David; Lundwall, Åke (Jun 2006). "Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005". Biol Chem. 387 (6): 635–824. doi:10.1515/BC.2006.081. PMID 16800723. S2CID 83910246.
  7. ^ a b "Entrez Gene: KLK12 kallikrein-related peptidase 12".

Further reading

External links


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