KLK13kmpll
Identifiers
AliasesKLK13, KLK-L4, KLKL4, kallikrein related peptidase 13
External IDsOMIM: 605505 MGI: 3615275 HomoloGene: 56714 GeneCards: KLK13
Orthologs
SpeciesHumanMouse
Entrez

26085

626834

Ensembl

n/a

ENSMUSG00000054046

UniProt

Q9UKR3
Q5BQ95
Q5BQ97

n/a

RefSeq (mRNA)

NM_015596

NM_001039042

RefSeq (protein)

NP_056411
NP_001335106
NP_001335107

n/a

Location (UCSC)n/aChr 7: 43.36 – 43.38 Mb
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Kallikrein-13 is a protein that in humans is encoded by the KLK13 gene.[4][5][6]

Function

Kallikreins are a subgroup of serine proteases having diverse physiological functions.

As of 2022, the precise physiological functions of Kallikrein 13 remain unknown. It may play a role in the defense of the upper digestive apparatus, in extracellular matrix degradation, in tissue remodelling, and in the male reproductive organs.

This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Expression of this gene is regulated by steroid hormones and may be useful as a marker for breast cancer. An additional transcript variant has been identified, but its full length sequence has not been determined.[6]

Kallikrein-13 serves as a priming protease during infection by the human coronavirus HKU1.[7]

Many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers.

References

  1. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000054046 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ Lundwall A, Band V, Blaber M, Clements JA, Courty Y, Diamandis EP, Fritz H, Lilja H, Malm J, Maltais LJ, Olsson AY, Petraki C, Scorilas A, Sotiropoulou G, Stenman UH, Stephan C, Talieri M, Yousef GM (Jun 2006). "A comprehensive nomenclature for serine proteases with homology to tissue kallikreins" (PDF). Biol Chem. 387 (6): 637–41. doi:10.1515/BC.2006.082. PMID 16800724. S2CID 436200.
  5. ^ Diamandis EP, Deperthes D, Lundwall Å (Jun 2006). "Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005". Biol Chem. 387 (6): 635–824. doi:10.1515/BC.2006.081. PMID 16800723. S2CID 83910246.
  6. ^ a b "Entrez Gene: KLK13 kallikrein-related peptidase 13".
  7. ^ Milewska A, Falkowski K, Kulczycka M, Bielecka E, Naskalska A, Mak P, Lesner A, Ochman M, Urlik M, Diamandis E, Prassas I, Potempa J, Kantyka T, Pyrc K (2020). "Kallikrein 13 serves as a priming protease during infection by the human coronavirus HKU1". Science Signaling. 13 (659): eaba9902. doi:10.1126/scisignal.aba9902. PMC 7857416. PMID 33234691.

Further reading

External links

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