KLK15
Identifiers
AliasesKLK15, ACO, HSRNASPH, kallikrein related peptidase 15
External IDsOMIM: 610601 MGI: 2447533 HomoloGene: 77571 GeneCards: KLK15
Orthologs
SpeciesHumanMouse
Entrez

55554

317652

Ensembl

ENSG00000174562

ENSMUSG00000055193

UniProt

Q9H2R5

n/a

RefSeq (mRNA)

NM_174865

RefSeq (protein)

NP_001264010
NP_001264011
NP_059979

n/a

Location (UCSC)Chr 19: 50.83 – 50.84 MbChr 7: 43.58 – 43.59 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Kallikrein-15 is a protein that in humans is encoded by the KLK15 gene.[5][6][7][8][9]

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. In prostate cancer, this gene has increased expression, which indicates its possible use as a diagnostic or prognostic marker for prostate cancer. The gene contains multiple polyadenylation sites and alternative splicing results in multiple transcript variants encoding distinct isoforms.[9]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000174562 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000055193 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Yousef GM, Scorilas A, Jung K, Ashworth LK, Diamandis EP (Feb 2001). "Molecular cloning of the human kallikrein 15 gene (KLK15). Up-regulation in prostate cancer". J Biol Chem. 276 (1): 53–61. doi:10.1074/jbc.M005432200. PMID 11010966.
  6. ^ Yousef GM, Scorilas A, Magklara A, Memari N, Ponzone R, Sismondi P, Biglia N, Abd Ellatif M, Diamandis EP (Nov 2002). "The androgen-regulated gene human kallikrein 15 (KLK15) is an independent and favourable prognostic marker for breast cancer". Br J Cancer. 87 (11): 1294–300. doi:10.1038/sj.bjc.6600590. PMC 2408911. PMID 12439720.
  7. ^ Lundwall A, Band V, Blaber M, Clements JA, Courty Y, Diamandis EP, Fritz H, Lilja H, Malm J, Maltais LJ, Olsson AY, Petraki C, Scorilas A, Sotiropoulou G, Stenman UH, Stephan C, Talieri M, Yousef GM (Jun 2006). "A comprehensive nomenclature for serine proteases with homology to tissue kallikreins" (PDF). Biol Chem. 387 (6): 637–41. doi:10.1515/BC.2006.082. PMID 16800724. S2CID 436200.
  8. ^ Diamandis, Eleftherios P.; Deperthes, David; Lundwall, Åke (Jun 2006). "Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005". Biol Chem. 387 (6): 635–824. doi:10.1515/BC.2006.081. PMID 16800723. S2CID 83910246.
  9. ^ a b "Entrez Gene: KLK15 kallikrein-related peptidase 15".

Further reading

External links


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