KML-010
KML-010 structure.png
Identifiers
  • 8-[4-(4-fluorophenyl)-4-oxobutyl]-1-methyl-1,3,8-triazaspiro[4.5]decan-4-one
CAS Number
PubChem CID
ChemSpider
UNII
Chemical and physical data
FormulaC18H24FN3O2
Molar mass333.407 g·mol−1
3D model (JSmol)
  • O=C1NCN(C)C1(CC2)CCN2CCCC(=O)c(cc3)ccc3F
  • InChI=1S/C18H24FN3O2/c1-21-13-20-17(24)18(21)8-11-22(12-9-18)10-2-3-16(23)14-4-6-15(19)7-5-14/h4-7H,2-3,8-13H2,1H3,(H,20,24)
  • Key:GRADLHIYNHRBCW-UHFFFAOYSA-N
  (verify)

KML-010 is a drug derived from spiperone. It functions as a highly selective 5-HT2A receptor antagonist, with negligible affinity for the 5-HT1A or 5-HT2C receptors, and over 400-fold lower affinity for the D2 receptor in comparison to spiperone.[1]

See also

References

  1. ^ Glennon RA, Metwally K, Dukat M, Ismaiel AM, De los Angeles J, Herndon J, Teitler M, Khorana N (June 2002). "Ketanserin and spiperone as templates for novel serotonin 5-HT(2A) antagonists". Current Topics in Medicinal Chemistry. 2 (6): 539–58. doi:10.2174/1568026023393787. PMID 12052193.