KRT81
Identifiers
Aliases	KRT81, HB1, Hb-1, KRTHB1, MLN137, ghHkb1, hHAKB2-1, keratin 81, K81
External IDs	OMIM: 602153 MGI: 1928858 HomoloGene: 55645 GeneCards: KRT81
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q13.13 Start 52,285,913 bp[1] End 52,291,534 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15 F2|15 56.9 cM Start 101,356,942 bp[2] End 101,361,632 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in hair follicle placenta mammary gland breast amniotic fluid right coronary artery bone superior frontal gyrus mouth salivary gland Top expressed in lip right ventricle hair follicle skin of back skin of abdomen motor neuron sternocleidomastoid muscle upper arm medial ganglionic eminence tracheobronchial tree More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding structural molecule activity Cellular component intermediate filament keratin filament extracellular space cytosol Biological process keratinization cornification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3887 64818 Ensembl ENSG00000205426 ENSMUSG00000067615 UniProt Q14533 Q9ERE2 RefSeq (mRNA) NM_002281 NM_001166157 RefSeq (protein) NP_002272 NP_001159629 Location (UCSC) Chr 12: 52.29 – 52.29 Mb Chr 15: 101.36 – 101.36 Mb PubMed search [3] [4]
Wikidata
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Keratin, type II cuticular Hb1 is a protein that in humans is encoded by the KRT81 gene.^[5][6][7]

The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin, as well as KRTHB3 and KRTHB6, is found primarily in the hair cortex. Mutations in this gene and KRTHB6 have been observed in patients with a rare dominant hair disease, monilethrix.^[7]