KTN1
Identifiers
Aliases	KTN1, CG1, KNT, MU-RMS-40.19, kinectin 1
External IDs	OMIM: 600381 HomoloGene: 135663 GeneCards: KTN1
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q22.3 Start 55,559,072 bp[1] End 55,701,526 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm biceps brachii renal medulla vastus lateralis muscle body of tongue Achilles tendon gastrocnemius muscle deltoid muscle optic nerve corpus callosum n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding kinesin binding RNA binding cadherin binding Cellular component integral component of membrane integral component of plasma membrane endoplasmic reticulum membrane endoplasmic reticulum membrane endoplasmic reticulum lumen Biological process microtubule-based movement post-translational protein modification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3895 n/a Ensembl ENSG00000126777 n/a UniProt Q86UP2 n/a RefSeq (mRNA) NM_001079521 NM_001079522 NM_001271014 NM_004986 NM_182926 n/a RefSeq (protein) NP_001072989 NP_001072990 NP_001257943 NP_004977 n/a Location (UCSC) Chr 14: 55.56 – 55.7 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Kinectin is a protein that in humans is encoded by the KTN1 gene.^[3][4]

Function

Various cellular organelles and vesicles are transported along the microtubules in the cytoplasm. Likewise, membrane recycling of the endoplasmic reticulum (ER), Golgi assembly at the microtubule organizing center, and alignment of lysosomes along microtubules are all related processes. The transport of organelles requires a special class of microtubule-associated proteins (MAPs). One of these is the molecular motor kinesin (see MIM 148760 and MIM 600025), an ATPase that moves vesicles unidirectionally toward the plus end of the microtubule. Another such MAP is kinectin, a large integral ER membrane protein. Antibodies directed against kinectin have been shown to inhibit its binding to kinesin.[supplied by OMIM]^[4]

Interactions

KTN1 has been shown to interact with EEF1D,^[5] RhoG^[6][7] and RHOA.^[6][7][8][9]