KRT17
Identifiers
AliasesKRT17, K17, PC, PC2, PCHC1, 39.1, CK-17, keratin 17
External IDsOMIM: 148069 MGI: 96691 HomoloGene: 363 GeneCards: KRT17
Orthologs
SpeciesHumanMouse
Entrez

3872

16667

Ensembl

ENSG00000128422

ENSMUSG00000035557

UniProt

Q04695

Q9QWL7

RefSeq (mRNA)

NM_000422

NM_010663

RefSeq (protein)

NP_000413

NP_034793

Location (UCSC)Chr 17: 41.62 – 41.62 MbChr 11: 100.15 – 100.15 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Keratin, type I cytoskeletal 17 is a protein that in humans is encoded by the KRT17 gene.[5][6][7][8]

Keratin 17 is a type I cytokeratin. It is found in nail beds, hair follicles, sebaceous glands, and other epidermal appendages. Mutations in the gene encoding this protein lead to PC-K17 (previously known as Jackson-Lawler) type pachyonychia congenita and steatocystoma multiplex.[8]

Interactions

Keratin 17 has been shown to interact with CCDC85B.[9]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000128422 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035557 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ McLean WH, Rugg EL, Lunny DP, Morley SM, Lane EB, Swensson O, Dopping-Hepenstal PJ, Griffiths WA, Eady RA, Higgins C (Jul 1995). "Keratin 16 and keratin 17 mutations cause pachyonychia congenita". Nat Genet. 9 (3): 273–8. doi:10.1038/ng0395-273. PMID 7539673. S2CID 1873772.
  6. ^ Troyanovsky SM, Leube RE, Franke WW (Jan 1993). "Characterization of the human gene encoding cytokeratin 17 and its expression pattern". Eur J Cell Biol. 59 (1): 127–37. PMID 1281771.
  7. ^ Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW (Jul 2006). "New consensus nomenclature for mammalian keratins". J Cell Biol. 174 (2): 169–74. doi:10.1083/jcb.200603161. PMC 2064177. PMID 16831889.
  8. ^ a b "Entrez Gene: KRT17 keratin 17".
  9. ^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

Further reading

External links


Proteins of the cytoskeleton
Categories