KRT20
Identifiers
AliasesKRT20, CD20, CK-20, CK20, K20, KRT21, keratin 20
External IDsOMIM: 608218 MGI: 1914059 HomoloGene: 56837 GeneCards: KRT20
Orthologs
SpeciesHumanMouse
Entrez

54474

66809

Ensembl

ENSG00000171431
ENSG00000263057

ENSMUSG00000035775

UniProt

P35900

Q9D312

RefSeq (mRNA)

NM_019010

NM_023256

RefSeq (protein)

NP_061883

NP_075745

Location (UCSC)Chr 17: 40.88 – 40.89 MbChr 11: 99.32 – 99.33 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Keratin 20, often abbreviated CK20, is a protein that in humans is encoded by the KRT20 gene.[5][6][7]

Keratin 20 is a type I cytokeratin. It is a major cellular protein of mature enterocytes and goblet cells and is specifically found in the gastric and intestinal mucosa.[8]

In immunohistochemistry, antibodies to CK20 can be used to identify a range of adenocarcinoma arising from epithelia that normally contain the CK20 protein. For example, the protein is commonly found in colorectal cancer, transitional cell carcinomas and in Merkel cell carcinoma, but is absent in lung cancer, prostate cancer, and non-mucinous ovarian cancer. It is often used in combination with antibodies to CK7 to distinguish different types of glandular tumour.[9]

Micrograph showing CK20 immunostaining of normal small intestine.

References

  1. ^ a b c ENSG00000263057 GRCh38: Ensembl release 89: ENSG00000171431, ENSG00000263057 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035775 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Moll R, Zimbelmann R, Goldschmidt MD, Keith M, Laufer J, Kasper M, Koch PJ, Franke WW (June 1993). "The human gene encoding cytokeratin 20 and its expression during fetal development and in gastrointestinal carcinomas". Differentiation. 53 (2): 75–93. doi:10.1111/j.1432-0436.1993.tb00648.x. PMID 8359595.
  6. ^ Ye X, Li Y, Hou G, Liu Z, Chen T (May 2002). "[Significance of cytokeratin gene (CK-20 mRNA) expression in metastatic lymph nodes in colon carcinoma patients]". Zhonghua Zhong Liu Za Zhi (in Chinese). 24 (3): 261–3. PMID 12515621.
  7. ^ Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW (July 2006). "New consensus nomenclature for mammalian keratins". J. Cell Biol. 174 (2): 169–74. doi:10.1083/jcb.200603161. PMC 2064177. PMID 16831889.
  8. ^ Moll R, Schiller DL, Franke WW (August 1990). "Identification of protein IT of the intestinal cytoskeleton as a novel type I cytokeratin with unusual properties and expression patterns". J. Cell Biol. 111 (2): 567–80. doi:10.1083/jcb.111.2.567. PMC 2116178. PMID 1696264.
  9. ^ Leong, Anthony S-Y; Cooper, Kumarason; Leong, F Joel W-M (2003). Manual of Diagnostic Cytology (2 ed.). Greenwich Medical Media, Ltd. pp. 171–172. ISBN 1-84110-100-1.

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