Khachatryan or Khachatrian (Armenian: Խաչատրյան) is an Armenian surname. It may refer to the following notable people:

• Aleksandr Khachatryan (born 1947), Armenian actor
• Andranik Khachatryan (born 1956), Armenian footballer
• Ara Khachatryan (born 1982), Armenian weightlifter
• Arkadi Khachatryan (born 1975), Armenian politician
• Armine Khachatryan (born 1986), Armenian women's footballer
• Artur Khachatryan (born 1983), Armenian boxer
• Ashot Khachatryan (born 1959), Armenian footballer
• Eva Khachatryan (born 1990), Armenian actress
• Gagik Khachatryan (politician), Armenian politician
• Gagik Khachatryan (weightlifter) (born 1971), Armenian weightlifter
• Garegin Khachatryan (1975–1995), Armenian sculptor, artist and a dissident
• Gevorg Khachatrian (1936–1996), Armenian scientist
• Harutyun Khachatryan (born 1955), Armenian film director
• Karen Khachatrian (born 1962), Armenian scientist
• Kristine Khachatryan, Armenian cross-country skier
• Marinka Khachatryan, Armenian actress
• Mher Khachatryan (born 1989), Armenian actor
• Mher Khachatryan (painter) (born 1983), Armenian painter
• Rafik Khachatryan (1937–1993), Armenian sculptor
• Romik Khachatryan (born 1978), Armenian football player
• Samson Khachatryan (born 1960), Armenian boxer
• Sargis Khachatryan (born 1964), Armenian footballer
• Sargis Khachatryan (wrestler), Brazilian wrestler
• Sergey Khachatryan (born 1985), Armenian violinist
• Shahen Khachatrian (born 1934), Armenian art historian
• Suren Khachatryan (born 1956), Armenian politician
• Tiran Khachatryan (born 1977), Armenian general
• Vardan Khachatryan (born 1968), Armenian football player
• Vahagn Khachatryan (born 1959), Armenian politician
• Vladik Khachatryan, politician from the Republic of Artsakh

and objects:

• 18174 Khachatryan