Khatme Nabuwwat (also spelt Khatme Nabuwat or Khatme Nubuwwat) refers to the Islamic concept of the Seal of the Prophets, declaring the finality of prophets ending with Muhammad.

It may also refer to:

• Majlis-e-Tahaffuz-e-Khatme Nabuwwat, a Pakistani organisation devoted to protecting the concept of Khatme Nabuwwat
• International Majlis-e Tahaffuz-e-Khatm-e Nobuwat Bangladesh (IKNMB), an anti-Ahmadiyya organisation in Bangladesh
• Khatme Nabuwat Andolon Bangladesh, an anti-Ahmadiyya splinter group of IKNMB
• Khatme Nubuwwat Academy, an anti-Ahmadiyya organisation in London.