The Kowalski ester homologation is a chemical reaction for the homologation of esters.^[1][2]

This reaction was designed as a safer alternative to the Arndt–Eistert synthesis, avoiding the need for diazomethane. The Kowalski reaction is named after its inventor, Conrad J. Kowalski.

Reaction mechanism

The mechanism is disputed.^{[further explanation needed]}

Variations

By changing the reagent in the second step of the reaction, the Kowalski ester homologation can also be used for the preparation of silyl ynol ethers.^{[citation needed]}