Tigress catches River Fever, a deadly disease that can only be cured by the rare sun orchid found in the Valley of the Scorpion. Unaware of the danger that lies ahead of them, Po and Monkey set out to find the orchid, but Monkey is caught and brainwashed by the evil Scorpion. Po must now find the orchid and fend off his brainwashed friend before Tigress dies.

Villain: Scorpion

Po, Tigress and Mantis must escort an Emperor's daughter Mei Li on a peacemaking visit to the Qidan clan. Yet Princess Mei Li and her caravan are targeted by crocodile bandits led by Fung. They soon discover that Princess Mei Li will be given to the Qidan King Temutai as a servant in exchange for peace between the kingdoms.

Villains: Temutai and Fung & the Croc Bandits

Po accidentally destroys the training equipment in the Jade Palace and invites a mechanical genius named Taotie to fix it. Unknown to Po, Taotie is an old enemy of Shifu's and this invitation was all he needed to seek his revenge.

Po is driving Tigress nuts with his fanboy ways while they are on a mission together. Things get worse when they are attacked by Fung and the Croc Bandits and fight together. There's one problem: They're chained together. Can they defeat the croc bandits and save Shifu's statue?

Villains: Fung & the Croc Bandits

Po discovers a rare secret move which causes temporary memory loss, but things get out of hand when he uses it on the Furious Five too often. While Po and Master Shifu find a way to undo this, Taotie begins his next attempt to get revenge on Master Shifu using the amnesiac Furious Five to his advantage.

Fung helps Po out of a hole and Po agrees to return the favor. But he quickly learns that repaying a favor to Fung might be more difficult than he imagined when Fung states to Po that his brother has been captured by the soldiers of Jong Sung Jai Kai Chow.

Po goes undercover as a prisoner in Chor-Ghom Prison to learn where a diabolical criminal named Tong Fo has hidden the ultra-dangerous weapon called the Sacred War Hammer of Lei Lang.

Upon thwarting a raid on the Jade Palace from Temutai and the Qidan Clan with incredible new powers and abilities and fighting styles, Po learns that there have been many Furious Fives before the current one and that the most powerful member has always become evil. He even wonders this when he encounters the most powerful member of the original Furious Five, a strong, powerful owl named Fenghuang.

After an incident with the Mystical Mirror of Yin and Yang, Po is acting strangely....he's light, sweet, generous, and kind one minute, then dark, mean, greedy, and violent the next. While word is going around that there might be two of him. Soon the truth comes out, the Mystic Yin Yang Mirror split Po into separate versions of himself: one good and one evil. Now Shifu and the Furious Five must recombine Po's aggressive self with his compassionate self before sunset or the division will become permanent and Bad Po will be unstoppable!

Two Kung Fu masters named Master Chao and Master Junjie visit the Jade Palace to check up on Shifu. But when Master Junjie encourages Po to take a peek at their sparring, which is only for the presence of the three masters, it causes the downfall of Shifu and the Furious Five, and Master Junjie replaces the Furious Five members and Po with a team of Kung Fu snow leopards. When his friends turn their backs on him, Po decides to set things right and find out Junjie's plans.

On Dragon Warrior Day, Po befriends a bitter rhino named Hundun and helps him get back on his feet—until he learns that Hundun's secret goal is to destroy the Dragon Warrior. Po learns that Hundun is bitter about the day when Tai Lung escaped from Chor-Gom Prison (where Hundun used to work at) and Tai Lung's defeat leaving him without a job.

Villain: Hundun

When Mr. Ping's noodle shop is destroyed during Po's fight with three pigs named Bao, Lao, and Tsao who want to learn secret Kung Fu moves, Po reluctantly invites him to stay at the Jade Palace. Before long, Mr. Ping's annoying and controlling ways make themselves known as he drives Po, Shifu and the Furious Five crazy. Bao, Lao, and Tsao soon return and plan to learn the secret moves upon capturing Master Shifu. However, they mistake Mr. Ping for Master Shifu.

The Ghost of Grand Master Oogway returns to the Jade Palace to mentor Po, throwing Po and Shifu's relationship into turmoil. Unbeknownst to Po and Shifu, the Ghost of Grand Master Oogway is actually the wicked Master Junjie in disguise in his next plot to rule the Jade Palace.

When a Kung Fu prodigy named Peng arrives at the Jade Palace, Po's enthusiasm begins to sour when he gets a little jealous of the attention being heaped onto the young master. Meanwhile, Temutai takes interest in Peng and plans to pit his own nephew Jing Mei against Peng. At the end, it is unveiled that Peng is Tai Lung's nephew.

Po befriends a troupe of dancers called the Ladies of the Shade, where he falls for one of the dancers named Song, unaware that they are actually a band of traveling thieves. When the Dragon Chalice (which Grand Master Oogway gave to Master Shifu) goes missing from the Jade Palace, Po (alongside Master Crane and Master Viper) has to disguise himself to infiltrate the band.

After sending Taotie to jail, Po is forced to care for his son, Bian Zao. Po is yet to determine if Bian Zao really adores him, or if he is just using him to double-cross the panda.

In order to impress his fan club, Po releases a supernatural, monstrous creature called the Mongolian Fist Demon so that he can vanquish the beast in battle—which doesn't exactly go his way.

Po is shocked when Shifu informs him that today is "Dragon Warrior Challenge Day." If anyone can defeat Po in battle before sundown, they will become the next Dragon Warrior! One of the challengers to defeat Po ends up being Hundun. But, at the end, Shifu reveals that he made it up.

Po helps Shifu channel his "inner Po" as they try to keep a visiting Kung Fu Master named Master Yao out of Temutai's clutches.

When the Furious Five go out of town, Po has to rely on a Mr. Ping and elderly mahjong player Mr. Yeung and Mrs. Gow for back-up when Temutai and the Qidan Clan are seeking the Helmet of the Invincible Thunder Kick.

Po discovers that his favorite wrestler named Kwan is coming to the Valley of Peace, and he is invited to meet his hero in person. Kwan looks weak and feeble as an elderly old ram, and he tells Po that this would be his last fight. Po helps Kwan become strong again, but is tricked. It turns out that Kwan was plotting revenge because of an incident with Po's dumpling (which Po doesn't know about) when he was a panda cub. The dumpling went flying into the air and hit Kwan, which turned him into a wimp. Crane goes back after meeting with Kwan in person, but finds out he isn't weak and feeble at all. He tries to help his love interest Bai Li, but is knocked out by her. He escapes and barely saves Po. Crane tells Po about how strong Kwan really is and Po gets his game on. Po wins at first, but then he lets Kwan win too, which makes it a tie. Then Kwan asked if he could repay Po anyway, so Po asked if he could sign his belly.

Po tries to get his father a girlfriend, but changes his mind when Mr. Ping reveals he already has a girlfriend, which is none other than Master Scorpion herself. Unfortunately, she isn't exactly Po's favorite person. It is later discovered that it is all a ruse to get revenge on Po.

Villain: Scorpion

Po has to find an awesome trophy for the Hall of Heroes or risk being humiliated in front of the entire village at the upcoming Warrior Festival. During the search for this, Po comes to the aid of Han, whose doll is being targeted by the soldiers of Jong Sung Jai Kai Chow.

When Shifu's father Shirong returns to the Jade Palace, Po thinks the family reunion will be so sweet. He soon learns that Shifu and his father don't get along.

There's a crime wave sweeping the Valley of Peace, but Po's enthusiasm for busting crime takes a hit when he discovers that the culprit might be Monkey.