Kyrie is a unisex given name. Notable people with the name include:

• Kyrie Irving (born 1992), American basketball player
• Kyrie Kristmanson (born 1989 or 1990), Canadian singer, songwriter, and musician
• Kyrie O'Connor (born 1954), American writer and newspaper editor
• Kyrie Wilson (born 1992), American gridiron football player

Fictional characters

• Kyrie, the female lead in the video game Devil May Cry 4
• Kyrie Canaan, a female character in the video game Final Fantasy VII Remake and the novel Final Fantasy VII The Kids Are Alright: A Turks Side Story
• Kyrie Florian, a female main character in the game Mahou Shoujo Lyrical Nanoha A's Portable: The Gears of Destiny
• Kyrie Illunis, male protagonist of the Nintendo DS video game Sands of Destruction
• Kyrie Ushiromiya, a female supporting character in the visual novel, manga, and anime series Umineko no Naku Koro ni