EIF2D
Identifiers
Aliases	EIF2D, HCA56, LGTN, eukaryotic translation initiation factor 2D
External IDs	OMIM: 613709 MGI: 109342 HomoloGene: 38244 GeneCards: EIF2D
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q32.1 Start 206,571,292 bp[1] End 206,612,465 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 E4|1 56.9 cM Start 131,080,918 bp[2] End 131,115,395 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube parotid gland body of pancreas canal of the cervix tibial nerve triceps brachii muscle left lobe of thyroid gland body of stomach gastrocnemius muscle right lobe of thyroid gland Top expressed in Paneth cell fossa condyle hair follicle internal carotid artery lacrimal gland primitive streak external carotid artery endocardial cushion vas deferens More reference expression data BioGPS More reference expression data
Gene ontology Molecular function translation initiation factor activity RNA binding signaling receptor activity Cellular component cytoplasm cytosolic small ribosomal subunit cytosol nuclear body Biological process translational initiation intracellular protein transport ribosome disassembly protein biosynthesis formation of translation preinitiation complex IRES-dependent viral translational initiation signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1939 16865 Ensembl ENSG00000143486 ENSMUSG00000026427 UniProt P41214 Q5SY38 Q61211 RefSeq (mRNA) NM_001201478 NM_006893 NM_001136070 NM_010709 RefSeq (protein) NP_001188407 NP_008824 NP_001129542 NP_034839 Location (UCSC) Chr 1: 206.57 – 206.61 Mb Chr 1: 131.08 – 131.12 Mb PubMed search [3] [4]
Wikidata
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Ligatin, otherwise known as eIF2D, is a protein that in humans is encoded by the LGTN gene.^[5][6] This protein is not a component of the heterotrimeric eIF2 complex, but instead functions in different pathways of eukaryotic translation.

Function

This gene encodes a protein receptor that localizes phosphoglycoproteins within endosomes and at the cell periphery. This trafficking receptor for phosphoglycoproteins may play a role in neuroplasticity by modulating cell-cell interactions, intracellular adhesion, and protein binding at membrane surfaces. In hippocampal neurons, long-lasting down-regulation of ligation mRNA levels occurs via post-transcriptional RNA processing following glutamate receptor activation. This protein contains single PUA and SUI1 domains and these domains may function in RNA binding and translation initiation, respectively.^[6]