LILRB3
Identifiers
AliasesLILRB3, CD85A, HL9, ILT-5, ILT5, LILRA6, LIR-3, LIR3, PIRB, PIR-B, leukocyte immunoglobulin like receptor B3
External IDsOMIM: 604820 MGI: 1195974 HomoloGene: 134028 GeneCards: LILRB3
Orthologs
SpeciesHumanMouse
Entrez

11025

18729

Ensembl

ENSG00000275019
ENSG00000274587
ENSG00000277816
ENSG00000204577

n/a

UniProt

Q6PI73
O75022

n/a

RefSeq (mRNA)

NM_001081450
NM_006864
NM_001320960

NM_001289428
NM_008848
NM_011093

RefSeq (protein)

XP_006726238.1
XP_006726376
XP_006726377
XP_011546876
XP_011546877

n/a

Location (UCSC)Chr 19: 54.22 – 54.22 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Leukocyte immunoglobulin-like receptor subfamily B member 3 is a protein that in humans is encoded by the LILRB3 gene.[4][5][6]

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells and is believed to be a myeloid checkpoint. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.[6]

See also

References

  1. ^ a b c ENSG00000274587, ENSG00000277816, ENSG00000204577 GRCh38: Ensembl release 89: ENSG00000275019, ENSG00000274587, ENSG00000277816, ENSG00000204577 – Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ Arm JP, Nwankwo C, Austen KF (Sep 1997). "Molecular identification of a novel family of human Ig superfamily members that possess immunoreceptor tyrosine-based inhibition motifs and homology to the mouse gp49B1 inhibitory receptor". J Immunol. 159 (5): 2342–9. doi:10.4049/jimmunol.159.5.2342. PMID 9278324.
  5. ^ Colonna M, Navarro F, Bellon T, Llano M, Garcia P, Samaridis J, Angman L, Cella M, Lopez-Botet M (Dec 1997). "A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells". J Exp Med. 186 (11): 1809–18. doi:10.1084/jem.186.11.1809. PMC 2199153. PMID 9382880.
  6. ^ a b "Entrez Gene: LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3".

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


Proteins: clusters of differentiation (see also list of human clusters of differentiation)
Categories