LIN7A

Identifiers

LIN7A, LIN-7A, LIN7, MALS-1, TIP-33, VELI1, lin-7 homolog A, crumbs cell polarity complex component, MALS1

External IDs

OMIM: 603380 MGI: 2135609 HomoloGene: 20976 GeneCards: LIN7A

Gene location (Human)

Chr.	Chromosome 12 (human)^[1]

Band	12q21.31	Start	80,792,520 bp^[1]
Band	12q21.31	End	80,937,934 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 10 (mouse)^[2]

Band	10\|10 D1	Start	107,107,547 bp^[2]
Band	10\|10 D1	End	107,257,335 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

Brodmann area 23

endothelial cell

middle temporal gyrus

retinal pigment epithelium

spongy bone

blood

cerebellar cortex

cerebellar hemisphere

entorhinal cortex

bone marrow

Top expressed in

seminiferous tubule

cerebellar vermis

nucleus accumbens

primary motor cortex

inferior colliculus

superior cervical ganglion

mammillary body

spermatocyte

Region I of hippocampus proper

spermatid

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	protein binding L27 domain binding
Cellular component	postsynaptic membrane membrane postsynaptic density cell-cell junction bicellular tight junction plasma membrane cell junction basolateral plasma membrane neuron projection extracellular exosome presynapse synapse MPP7-DLG1-LIN7 complex intracellular anatomical structure
Biological process	protein localization to basolateral plasma membrane maintenance of epithelial cell apical/basal polarity protein transport synaptic vesicle transport inner ear development neurotransmitter secretion exocytosis transport protein-containing complex assembly
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


8825


108030

Ensembl


ENSG00000111052


ENSMUSG00000019906

UniProt


O14910


Q8JZS0

RefSeq (mRNA)


NM_004664 NM_001324423


NM_001033223 NM_001039354 NM_001284329

RefSeq (protein)


NP_001311352 NP_004655


NP_001028395 NP_001034443 NP_001271258

Location (UCSC)

Chr 12: 80.79 – 80.94 Mb

Chr 10: 107.11 – 107.26 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Lin-7 homolog A is a protein that in humans is encoded by the LIN7A gene.^[5]^[6]^[7]

Interactions

LIN7A has been shown to interact with:

References

Rousset R, Fabre S, Desbois C, Bantignies F, Jalinot P (1998). "The C-terminus of the HTLV-1 Tax oncoprotein mediates interaction with the PDZ domain of cellular proteins". Oncogene. 16 (5): 643–54. doi:10.1038/sj.onc.1201567. PMID 9482110.
Butz S, Okamoto M, Südhof TC (1998). "A tripartite protein complex with the potential to couple synaptic vesicle exocytosis to cell adhesion in brain". Cell. 94 (6): 773–82. doi:10.1016/S0092-8674(00)81736-5. PMID 9753324. S2CID 12465062.
Borg JP, Straight SW, Kaech SM, de Taddéo-Borg M, Kroon DE, Karnak D, Turner RS, Kim SK, Margolis B (1998). "Identification of an evolutionarily conserved heterotrimeric protein complex involved in protein targeting". J. Biol. Chem. 273 (48): 31633–6. doi:10.1074/jbc.273.48.31633. PMID 9822620.
Borg JP, Lõpez-Figueroa MO, de Taddèo-Borg M, Kroon DE, Turner RS, Watson SJ, Margolis B (1999). "Molecular analysis of the X11-mLin-2/CASK complex in brain". J. Neurosci. 19 (4): 1307–16. doi:10.1523/JNEUROSCI.19-04-01307.1999. PMC 6786035. PMID 9952408.
Perego C, Vanoni C, Villa A, Longhi R, Kaech SM, Fröhli E, Hajnal A, Kim SK, Pietrini G (1999). "PDZ-mediated interactions retain the epithelial GABA transporter on the basolateral surface of polarized epithelial cells". EMBO J. 18 (9): 2384–93. doi:10.1093/emboj/18.9.2384. PMC 1171321. PMID 10228153.
Kamberov E, Makarova O, Roh M, Liu A, Karnak D, Straight S, Margolis B (2000). "Molecular cloning and characterization of Pals, proteins associated with mLin-7". J. Biol. Chem. 275 (15): 11425–31. doi:10.1074/jbc.275.15.11425. PMID 10753959.
Tseng TC, Marfatia SM, Bryant PJ, Pack S, Zhuang Z, O'Brien JE, Lin L, Hanada T, Chishti AH (2001). "VAM-1: a new member of the MAGUK family binds to human Veli-1 through a conserved domain". Biochim. Biophys. Acta. 1518 (3): 249–59. doi:10.1016/s0167-4781(01)00191-9. PMID 11311936.
Harris BZ, Venkatasubrahmanyam S, Lim WA (2002). "Coordinated folding and association of the LIN-2, -7 (L27) domain. An obligate heterodimerization involved in assembly of signaling and cell polarity complexes". J. Biol. Chem. 277 (38): 34902–8. doi:10.1074/jbc.M205856200. PMID 12110687.
Hori K, Konno D, Maruoka H, Sobue K (2003). "MALS is a binding partner of IRSp53 at cell-cell contacts". FEBS Lett. 554 (1–2): 30–4. doi:10.1016/S0014-5793(03)01074-3. PMID 14596909. S2CID 30329043.
Leonoudakis D, Conti LR, Radeke CM, McGuire LM, Vandenberg CA (2004). "A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels". J. Biol. Chem. 279 (18): 19051–63. doi:10.1074/jbc.M400284200. PMID 14960569.
Leonoudakis D, Conti LR, Anderson S, Radeke CM, McGuire LM, Adams ME, Froehner SC, Yates JR, Vandenberg CA (2004). "Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins". J. Biol. Chem. 279 (21): 22331–46. doi:10.1074/jbc.M400285200. PMID 15024025.
Olsen O, Wade JB, Morin N, Bredt DS, Welling PA (2005). "Differential localization of mammalian Lin-7 (MALS/Veli) PDZ proteins in the kidney". Am. J. Physiol. Renal Physiol. 288 (2): F345–52. doi:10.1152/ajprenal.00235.2004. PMID 15494546. S2CID 36221552.
Dode L, Andersen JP, Raeymaekers L, Missiaen L, Vilsen B, Wuytack F (2006). "Functional comparison between secretory pathway Ca2+/Mn2+-ATPase (SPCA) 1 and sarcoplasmic reticulum Ca2+-ATPase (SERCA) 1 isoforms by steady-state and transient kinetic analyses". J. Biol. Chem. 280 (47): 39124–34. doi:10.1074/jbc.M506181200. PMID 16192278.

v t e PDB gallery
2dkr: Solution structure of the PDZ domain from human Lin-7 homolog B

Interactions

References

Further reading