LPAR2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesLPAR2, EDG-4, EDG4, LPA-2, LPA2, lysophosphatidic acid receptor 2
External IDsOMIM: 605110 MGI: 1858422 HomoloGene: 3465 GeneCards: LPAR2
Orthologs
SpeciesHumanMouse
Entrez

9170

53978

Ensembl

ENSG00000064547

ENSMUSG00000031861

UniProt

Q9HBW0

Q9JL06
Q6P290

RefSeq (mRNA)

NM_004720
NM_001395660

NM_020028

RefSeq (protein)

NP_004711

NP_064412

Location (UCSC)Chr 19: 19.62 – 19.63 MbChr 8: 70.28 – 70.28 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Lysophosphatidic acid receptor 2 also known as LPA2 is a protein that in humans is encoded by the LPAR2 gene.[5][6][7] LPA2 is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA).[8]

Function

This gene encodes a member of family I of the G protein-coupled receptors, as well as the EDG family of proteins. This protein functions as a lysophosphatidic acid (LPA) receptor and contributes to Ca2+ mobilization, a critical cellular response to LPA in cells, through association with Gi and Gq proteins.[5]

Interactions

LPAR2 has been shown to interact with TRIP6.[9]

Evolution

Paralogues

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000064547 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031861 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: LPAR2 Lysophosphatidic acid receptor 2".
  6. ^ An S, Bleu T, Hallmark OG, Goetzl EJ (April 1998). "Characterization of a novel subtype of human G protein-coupled receptor for lysophosphatidic acid". J. Biol. Chem. 273 (14): 7906–10. doi:10.1074/jbc.273.14.7906. PMID 9525886.
  7. ^ An S, Bleu T, Zheng Y, Goetzl EJ (November 1998). "Recombinant human G protein-coupled lysophosphatidic acid receptors mediate intracellular calcium mobilization". Mol. Pharmacol. 54 (5): 881–8. doi:10.1124/mol.54.5.881. PMID 9804623. S2CID 37327084.
  8. ^ Choi JW, Herr DR, Noguchi K, Yung YC, Lee CW, Mutoh T, Lin ME, Teo ST, Park KE, Mosley AN, Chun J (January 2010). "LPA Receptors: Subtypes and Biological Actions". Annual Review of Pharmacology and Toxicology. 50 (1): 157–186. doi:10.1146/annurev.pharmtox.010909.105753. PMID 20055701.
  9. ^ Xu J, Lai Yun-Ju, Lin Weei-Chin, Lin Fang-Tsyr (March 2004). "TRIP6 enhances lysophosphatidic acid-induced cell migration by interacting with the lysophosphatidic acid 2 receptor". J. Biol. Chem. United States. 279 (11): 10459–68. doi:10.1074/jbc.M311891200. ISSN 0021-9258. PMC 3904432. PMID 14688263.
  10. ^ "GeneCards®: The Human Gene Database".
  11. ^ "Ensembl Genome Browser".

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Cell surface receptor: G protein-coupled receptors
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