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Lady Killer or Ladykiller may refer to:

Literature

Books

• The Lady-Killer, a 1902 book by Henry De Vere Stacpoole
• Lady Killer (novel), a 1951 novel by Anthony Gilbert
• Lady Killer, a 1958 novel by Ed McBain
• The Lady Killer, a 1993 novel written by Martina Cole
• Lady Killer, a novel in the Rosato & Associates series

Comics and short stories

• Lady Killer, a character in the Strangers (Malibu Comics) series
• Lady Killer (comic book), a comic book series by Joëlle Jones and Jamie S. Rich, published by Dark Horse Comics since 2015
• "Lady Killer", a story in the DC Comics anthology Weird Mystery Tales

Film and television

Films

• The Lady Killer (1913 film), a silent short
• Lady Killer (1933 film), starring James Cagney
• Lady Killer (1937 film) (Gueule d'amour), directed by Jean Grémillon
• Lady Killer (1992 film), a 1992 Yugoslavian film
• Lady Killer (1995 film), a drama directed by Steven Schachter
• Scene of the Crime (1996 film), also known as Ladykiller, starring Ben Gazzara
• The Lady Killer (2023 film), a Hindi language action-drama film

Television

• "Lady Killer" (Person of Interest), an episode of Person of Interest
• "Lady Killer", an episode of Charlie's Angels
• "Lady Killer", as episode of The Lone Ranger
• "Lady Killer", the first episode of Thriller
• "Lady Killer", an episode of The New Breed
• "Lady Killer", an episode of Riptide
• "Lady Killer", an episode of the reality series Life of Ryan
• "The Lady Killer", an episode of The Roy Rogers Show
• "The Lady Killer", half of a Cold Case Files episode
• "The Lady Killer", an episode of Pretty Little Liars

Music

• The Lady Killer (album), a 2010 album by CeeLo Green
• "Lady Killer" (Kreesa Turner song), by Canadian singer Kreesha Turner
• "Ladykillers" (song), a song by Lush
• "Lady Killer", a song on the John Entwistle album Mad Dog
• "Lady Killer", from the 2000 Spitfire album Race Riot
• "Ladykiller", a Maroon 5 song on the album Overexposed
• "Lady Killer", a Lita Ford song on the album Dancin' on the Edge
• "Lady Killer", from the debut album Flash and the Pan
• "Lady Killa", by British rapper M.I.A.
• "Lady Killer", a Racer X song on the album Second Heat
• "Lady Killer" by Andrew Jackson Jihad from the album Candy Cigarettes and Cap Guns
• "Ladykiller", by the Vandals, from their When in Rome Do as The Vandals album
• "Ladykiller", a song by the Saturdays from the "All Fired Up" single
• "Lady Killer", a song by Priestess from the album Prior to the Fire

Other uses

• Lady Killer, a variety of snow crocus