Lady Smith or Baroness Smith may refer to:

• Anne Smith, Lady Smith (born 1955), Senator of the College of Justice
• Angela Smith, Baroness Smith of Basildon (born 1959), leader of the Labour peers
• Elizabeth Smith, Baroness Smith of Gilmorehill (born 1940), widow of John Smith
• Carmen Smith, Baroness Smith of Llanfaes (born 1996), Plaid Cymru politician
• Julie Smith, Baroness Smith of Newnham (born 1969), Liberal Democrat academic
• Juana María de los Dolores de León Smith (1798–1872), wife of Sir Harry Smith, 1st Baronet
• Lady May Abel Smith (1906–1994), relative of the British royal family
• Lady Smith, a Splicer model in the video games BioShock and BioShock 2