Les or Leslie Smith may refer to:

Footballers

• Les Smith (footballer, born 1918) (1918–1995), footballer for England, Aston Villa and Brentford
• Les Smith (footballer, born 1920) (1920–2001), footballer for Oldham Athletic and Huddersfield Town
• Les Smith (footballer, born 1921) (1921–1993), English footballer for Mansfield Town
• Les Smith (footballer, born 1927) (1927–2008), footballer for Wolverhampton Wanderers and Aston Villa
• Les Smith (Australian footballer) (1900–1975), Australian rules footballer for Geelong
• Les Smith (footballer, born 1892) (1892–1968), Australian rules footballer for Melbourne
• Les Smith (footballer, born 1934), Australian rules footballer for Collingwood

Others

• Leslie Smith (businessman) (1918–2005), British entrepreneur; co-founder of Lesney Products and the Matchbox cars
• Leslie Smith (singer) (born 1949), American singer
• Les Smith (born 1967), British keyboard player
• Leslie Smith (skier) (born 1958), American former alpine skier
• Leslie Smith (fighter) (born 1982), American mixed martial arts fighter
• Leslie Smith III (born 1985), African American visual artist
• Leslie C. Smith, American military officer and Inspector General of the U.S. Army
• Leslie M. Smith (born 1961), American mathematician, mechanical engineer, and engineering physicist