LTK
Identifiers
Aliases	LTK, TYK1, Leukocyte receptor tyrosine kinase
External IDs	OMIM: 151520 MGI: 96840 HomoloGene: 130502 GeneCards: LTK
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q15.1 Start 41,503,637 bp[1] End 41,513,887 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 E5|2 59.97 cM Start 119,581,801 bp[2] End 119,590,912 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lung parotid gland upper lobe of left lung duodenum rectum jejunal mucosa body of stomach spleen gallbladder right lobe of liver Top expressed in entorhinal cortex visual cortex olfactory epithelium superior frontal gyrus primary motor cortex substantia nigra spermatocyte prefrontal cortex spermatid cingulate gyrus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity protein kinase activity nucleotide binding kinase activity transmembrane receptor protein tyrosine kinase activity protein tyrosine kinase activity ATP binding protein binding receptor tyrosine kinase transmembrane signaling receptor activity Cellular component integral component of membrane membrane plasma membrane integral component of plasma membrane intracellular anatomical structure cytoplasm receptor complex Biological process cellular response to retinoic acid phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway positive regulation of cardiac muscle cell apoptotic process negative regulation of apoptotic process protein phosphorylation positive regulation of neuron projection development phosphatidylinositol 3-kinase signaling cell population proliferation peptidyl-tyrosine phosphorylation signal transduction negative regulation of signal transduction cell differentiation positive regulation of ERK1 and ERK2 cascade regulation of neuron differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4058 17005 Ensembl ENSG00000062524 ENSMUSG00000027297 UniProt P29376 P08923 RefSeq (mRNA) NM_001135685 NM_002344 NM_206961 NM_008523 NM_203345 NM_206941 NM_206942 RefSeq (protein) NP_001129157 NP_002335 NP_996844 NP_032549 NP_976220 NP_996824 NP_996825 Location (UCSC) Chr 15: 41.5 – 41.51 Mb Chr 2: 119.58 – 119.59 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Leukocyte receptor tyrosine kinase is an enzyme that in humans is encoded by the LTK gene.^[5][6]

Function

The protein encoded by this gene is a member of the ALK/LTK receptor family of receptor tyrosine kinases (RTKs) whose ligand is unknown.^[7] Closely related to the insulin receptor family of RTKs. Tyrosine-specific phosphorylation of proteins is a key to the control of diverse pathways leading to cell growth and differentiation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.^[6]

Interactions

LTK has been shown to interact with IRS-1, Shc, and PIK3R1.^[8][9]