 Top: (R)-(−)-licarbazepine Bottom: (S)-(+)-licarbazepine | |
| Clinical data | |
|---|---|
| ATC code |
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| Pharmacokinetic data | |
| Protein binding | <40% |
| Metabolites | Glucuronides |
| Excretion | Mainly renal |
| Identifiers | |
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| CAS Number | |
| PubChem CID | |
| ChemSpider | |
| UNII | |
| KEGG | |
| ChEMBL | |
| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.122.427 |
| Chemical and physical data | |
| Formula | C15H14N2O2 |
| Molar mass | 254.289 g·mol−1 |
| 3D model (JSmol) | |
| Chirality | Racemic mixture |
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Licarbazepine is a voltage-gated sodium channel blocker with anticonvulsant and mood-stabilizing effects that is related to oxcarbazepine.[1] It is an active metabolite of oxcarbazepine.[1][2] In addition, an enantiomer of licarbazepine, eslicarbazepine ((S)-(+)-licarbazepine), is an active metabolite of eslicarbazepine acetate.[1][2] Oxcarbazepine and eslicarbazepine acetate are inactive on their own, and behave instead as prodrugs to licarbazepine and eslicarbazepine, respectively, to produce their therapeutic effects.[1][2]