Link domain | |||||||||
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Identifiers | |||||||||
Symbol | LINK | ||||||||
Pfam | PF00193 | ||||||||
Pfam clan | CL0056 | ||||||||
InterPro | IPR000538 | ||||||||
SMART | SM00445 | ||||||||
PROSITE | PDOC00955 | ||||||||
SCOP2 | 1o7b / SCOPe / SUPFAM | ||||||||
CDD | cd01102 | ||||||||
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A Link domain or Link module, also known as Xlink domain (X for extracellular), is a protein domain that binds to hyaluronic acid.[1] It is important in blood cell migration and apoptosis.[2] The link domain is found in some extracellular proteins in vertebrates such as the hyalectans.[3] It appears to be involved in extracellular matrix assembly and stability, cell adhesion, and migration.[3][4]
The structure has been shown to consist of two alpha helices and two antiparallel beta sheets arranged around a large hydrophobic core similar to that of C-type lectin.[5] This domain contains four conserved cysteines involved in two disulphide bonds. The link domain has also been termed HABM (hyaluronic acid binding module)[4] and PTR (proteoglycan tandem repeat).[6]
Proteins which contain the link domain include: