In 2003, there were 28 This American Life episodes.
- Episode 228 – "You Are So Beautiful... To Me"
- Episode 229 – "Secret Government"
- Act 1: Until the End of the War – Jack Hitt
- Act 2: Secret Trials and Secret Deportations – David Kestenbaum
- Act 3: Secret Wiretaps from a Secret Court – Blue Chevigny
- Episode 230 – "Come Back to Afghanistan"
- Episode 231 – "Time to Save the World"
- Act 1: The Rundown – Starlee Kine
- Act 2: Heather Help Me – Jessica Riddle
- Act 3: Fools Rush In, Where Mommies Fear to Tread
- Act 4: The Science of Good and Evil – Susan Drury
- Episode 232 – "The Real Story"
- Episode 233 – "Starting from Scratch"
- Act 1: Puppy Love – Molly FitzSimons
- Act 2: Making Money the Old Fashioned Way – Mary Beth Kirshner
- Act 3: The First Starting from Scratch – Jonathan Goldstein
- Episode 234 – "Say Anything"
- Episode 235 – "The Balloon Goes Up"
- Act 1: Bombs over Baghdad – Ira Glass
- Act 2: Tice Ridley is a first Lieutenant in the Army
- Act 3: What's French for French Fries? – David Sedaris
- Act 4: Fighting the Previous War – Sarah Vowell
- Act 5: What Peacetime Forgets about Wartime – Lee Sandlin
- Act 6: Lessons from Ancient Wars – Mary Zimmerman and Ira Glass
- Episode 236 – "My Two Cents"
- Act 1: Dave Knows – Susan Drury
- Act 2: Stock Making Sense – Alex Blumberg
- Act 3: A View from the Mop – Greg Tate
- Episode 237 – "Regime Change"
- Episode 238 – "Lost in Translation"
- Episode 239 – "Lost in America"
- Episode 240 – "I'm In Charge Now"
- Act 1: It's Not Just the Aces That Are Wild – David Sedaris
- Act 2: Playing Clinton in the Bush Leagues – Katy Vine
- Act 3: You Talkin' to Me? – Adam Davidson
- Episode 241 – "20 Acts in 60 Minutes"
- Act 1: Don't I Know You? – Tate Donovan and Starlee Kine
- Act 2: No of Course I Know You – Scott Carrier
- Act 3: It's Commerce that Brings Us Together – Susan Drury
- Act 4: The Sound of One Hand Waving – Patty Martin
- Act 5: The Sound of No Hands Clapping – Viki Merrick, Eric Kipp, and Jay Allison
- Act 6: Reaching Out with Radio – "Joey" and "Jake" with Blunt Youth Radio Project
- Act 7: Up Where the Air is Clear – Jonathan Goldstein
- Act 8: The Greatest Dog Name in the World – Valion Loetz, Paris Loetz and Katie Adone
- Act 9: Of Dogs and Men – Elaine Boehm and Jim Sultzer
- Act 10: Untitled – Neo-Futurists
- Act 11: Etiquette Lesson – David Sedaris
- Act 12: To Tell the Truth – Brent Runyon
- Act 13: More Lies – Catharyn and Ira Glass
- Act 14: Call in Colonel Mustard or That's What Happens when you Don't Use a Condoment Kids – Ira Glass
- Act 15: Mr. Prediction – David Rakoff
- Act 16: That One Guy at the Office – ?Drewdanna Gustafson?
- Act 17: You Can't Choose Your Gift – ?Richard Carry? and Jim Sultzer
- Act 18: Party Talk – Chuck Klosterman
- Act 19: The Hard Life at the Top – David Lipsky
- Act 20: The Greatest Moment I Saw On Stage – Ira Glass
- Episode 242 – "Enemy Camp"
- Act 1: Confession – Carl Marziali
- Act 2: Blood Agent – Ira Glass
- Act 3: And I Love Her – Etgar Keret
- Act 4: Yet another ineffective road map for world leadership – Blue Chevigny
- Episode 243 – "Later That Same Day"
- Episode 244 – "MacGyver"
- Episode 245 – "Allure of the Mean Friend"
- Episode 246 – "My Pen Pal"
- Act 1: Who Put the "Pistol" in "Epistolary"? – Ira Glass
- Act 2: Pen Pal Husband – Janice Powell
- Episode 247 – "What Is This Thing?"
- Episode 248 – "Like It Or Not"
- Episode 249 – "Garbage"
- Act 1: Oh, Mr. San Man – Ira Glass
- Act 2: Except for the Smell, I Think I Have a Crush on You – Luis Urrea
- Act 3: "I'm a Legitimate Businessman ... Waste Management."
- Episode 250 – "The Annoying Gap Between Theory and Practice"
- Episode 251 – "Brother's Keeper"
- Episode 252 – "Poultry Slam '03"
- Act 1: Duki
- Act 2: Winged Warrior
- Act 3: Chicken Diva – Jack Hitt
- Act 4: Trying to Respect the Chicken – Ira Glass
- Episode 253 – "The Middle of Nowhere"
- Episode 254 – "Teenage Embed, Part Two"
- Episode 255 – "This American Life's Holiday Gift-Giving Guide"
