This is a list of Cal State Fullerton Titans football players in the NFL Draft.
| B | Back | K | Kicker | NT | Nose tackle |
| C | Center | LB | Linebacker | FB | Fullback |
| DB | Defensive back | P | Punter | HB | Halfback |
| DE | Defensive end | QB | Quarterback | WR | Wide receiver |
| DT | Defensive tackle | RB | Running back | G | Guard |
| E | End | T | Offensive tackle | TE | Tight end |
| Year | Round | Pick | Overall | Player | Team | Position |
|---|---|---|---|---|---|---|
| 1977 | 10 | 16 | 267 | Aaron Ball | Tampa Bay Buccaneers | LB |
| 1981 | 8 | 9 | 202 | Bobby Kemp | Cincinnati Bengals | DB |
| 1984 | 9 | 15 | 239 | Lee Miller | San Francisco 49ers | DB |
| 1985 | 2 | 10 | 38 | Daren Gilbert | New Orleans Saints | T |
| 10 | 4 | 256 | Andre Pinesett | Indianapolis Colts | DT | |
| 1986 | 2 | 17 | 44 | Mark Collins | New York Giants | DB |
| 4 | 25 | 107 | James Pruitt | Miami Dolphins | WR | |
| 7 | 3 | 169 | Corn Redick | Philadelphia Eagles | WR | |
| 8 | 22 | 216 | Hank Goebel | Los Angeles Rams | T | |
| 1987 | 9 | 7 | 230 | Rick Calhoun | Detroit Lions | RB |
| 9 | 18 | 241 | Ron McLean | New York Jets | DT | |
| 1988 | 4 | 23 | 105 | James Thornton | Chicago Bears | TE |
| 7 | 11 | 176 | Todd White | Philadelphia Eagles | WR | |
| 1989 | 8 | 24 | 219 | Alex Stewart | Minnesota Vikings | DE |
| 9 | 5 | 228 | A. J. Jenkins | Pittsburgh Steelers | LB | |
| 9 | 23 | 246 | Jerry Leggett | New Orleans Saints | LB | |
| 1990 | 5 | 12 | 121 | Reggie Redding | Atlanta Falcons | G |
| 6 | 2 | 139 | Mike Pringle | Atlanta Falcons | RB | |
| 1992 | 10 | 7 | 259 | Reggie Yarbrough | Phoenix Cardinals | RB |