This is a list of the Canadian Billboard magazine Canadian Hot 100 number-ones of 2010.
Note that Billboard publishes charts with an issue date approximately 7–10 days in advance.
| † | Indicates best-performing single of 2010[1] |
| No. | Issue date | Song | Artist(s) | Reference |
|---|---|---|---|---|
| 31 | January 2 | "Tik Tok" | Kesha | [2] |
| January 9 | ||||
| January 16 | ||||
| January 23 | ||||
| January 30 | ||||
| February 6 | ||||
| February 13 | ||||
| 32 | February 20 | "Today Was a Fairytale" | Taylor Swift | [3] |
| 33 | February 27 | "I Believe" | Nikki Yanofsky | [4] |
| March 6 | ||||
| March 13 | ||||
| March 20 | ||||
| 34 | March 27 | "Wavin' Flag" | Young Artists for Haiti | [5] |
| April 3 | ||||
| April 10 | ||||
| April 17 | ||||
| April 24 | ||||
| May 1 | ||||
| 35 | May 8 | "Break Your Heart" | Taio Cruz featuring Ludacris | [6] |
| May 15 | ||||
| 36 | May 22 | "Not Afraid" | Eminem | [7] |
| 37 | May 29 | "California Gurls" † | Katy Perry featuring Snoop Dogg | [8] |
| June 5 | ||||
| June 12 | ||||
| June 19 | ||||
| June 26 | ||||
| July 3 | ||||
| July 10 | ||||
| July 17 | ||||
| July 24 | ||||
| 38 | July 31 | "Love the Way You Lie" | Eminem featuring Rihanna | [9] |
| August 7 | ||||
| August 14 | ||||
| August 21 | ||||
| August 28 | ||||
| September 4 | ||||
| September 11 | ||||
| 39 | September 18 | "Dynamite" | Taio Cruz | [10] |
| 40 | September 25 | "I Like It" | Enrique Iglesias featuring Pitbull | [11] |
| 41 | October 2 | "Only Girl (In the World)" | Rihanna | [12] |
| 42 | October 9 | "Just the Way You Are" | Bruno Mars | [13] |
| October 16 | ||||
| October 23 | ||||
| October 30 | ||||
| re | November 6 | "Only Girl (In the World)" | Rihanna | [14] |
| November 13 | ||||
| November 20 | ||||
| 43 | November 27 | "The Time (Dirty Bit)" | The Black Eyed Peas | [15] |
| December 4 | ||||
| December 11 | ||||
| 44 | December 18 | "Firework" | Katy Perry | [16] |
| re | December 25 | "The Time (Dirty Bit)" | The Black Eyed Peas | [17] |