In the last 100-plus years, the Chicago White Sox have had many players with colorful and memorable nicknames from "Shoeless Joe" Jackson to "Old Aches & Pains" Appling, Minnie the "Cuban Comet" Minoso, "Little Louie" Aparicio, "Black Jack" McDowell, and Frank "The Big Hurt" Thomas. These are some of the best.
- Dick Allen: "Wampum"
- Sandy Alomar Sr.: "Iron Pony"
- Luis Aparicio: "Little Louie"
- Luke Appling: "Fumblefoot" or "Kid Boots" or "Old Aches & Pains"
- Cuke Barrows, Roland Barrows: "Cuke"
- Bruno Block, James John Blochowicz: "Bruno"
- Ken Boyer: "Cap" or "Captain"
- Smoky Burgess, Forrest Harrill Burgess: "Smoky"
- Iván Calderón: "Ivan The Terrible"
- Norm Cash: "Stormin’ Norman"
- Eddie Cicotte: "Knuckles"
- Rocky Colavito, Rocco Colavito: "Rocky"
- Eddie Collins: "Cocky"
- José Contreras: "Commander"
- Joe Crede: "Clutch Norris"
- Bucky Dent, Russell Earl O’Day: "Bucky" or "Bucky 'Fucking' Dent"
- Octavio Dotel: "Ol' Dirty"
- Richard Dotson: "Dot"
- Brian Downing: "Incredible Hulk"
- Red Faber, Urban Clarence Faber: "Red"
- Carlton Fisk: "Pudge"
- Nellie Fox, Jacob Nelson Fox,: "Nellie", "Little Nel", or "The Mighty Mite"
- Freddy García: "Chief"
- Ralph Garr: "Road Runner"
- Kid Gleason, William Gleason: "Kid"
- Goose Gossage, Richard Michael Gossage: "Goose" or "The White Gorilla"
- Craig Grebeck: "The Little Hurt"
- Orlando Hernández: "El Duque"
- Bo Jackson, Vincent Edward Jackson: "Bo"
- Joe Jackson: "Shoeless Joe"
- Bobby Jenks: "Big Bad Bobby Jenks"
- Lance Johnson: "One Dog"
- Ron Karkovice: “The Officer”
- Ted Kluszewski: "Big Klu"
- Paul Konerko: "Paulie"
- Carlos Lee: "El Caballo"
- Ted Lyons: "Sunday Teddy"
- Nick Madrigal: "Nicky Two Strikes"
- Jack McDowell: "Black Jack"
- Catfish Metkovich, George Michael Metkovich: "Catfish"
- Minnie Miñoso, Saturnino Orestes Armas (Arrieta) Miñoso: "Minnie" or "The Cuban Comet"
- Dave Nicholson, "Big Nick"
- Blue Moon Odom, Johnny Lee Odom: "Blue Moon"
- Magglio Ordóñez: "El Caribe Mayor (The Caribbean Mayor)" or "Mags"
- Tom Paciorek: "Wimpy"
- Donn Pall: "The Pope"
- Herbert Perry: "The Milkman"
- Bubba Phillips, John Melvin Phillips: "Bubba"
- Billy Pierce: "Billy the Kid"
- Scott Podsednik: "Pods"
- Carlos Quentin: "TCQ"
- Tim Raines: "Rock"
- Alexei Ramírez: "The Cuban Missile"
- Ray Schalk: "The Cracker"
- Tom Seaver: "Tom Terrific"
- Bill Skowron: "Moose"
- Moose Solters, Julius Joseph Soltesz: "Moose" or "Lemons"
- Nick Swisher: "Dirty Thirty"
- Frank Thomas: "The Big Hurt"
- Jim Thome: "Big Jimmy" or "Mr. Incredible"
- Javier Vázquez: "The Silent Assassin"
- Robin Ventura: "Batman"
- Dayán Viciedo: "The Tank"
- Ed Walsh: "Big Ed"
- Skeeter Webb, James Laverne Webb: "Skeeter"
- Hoyt Wilhelm: "Old Sarge"
- Walt Williams: "No Neck"
- Taffy Wright, Taft Shedron Wright:: "Taffy"
- Early Wynn: "Gus"