During World War II, Nazi Germany developed many missiles and precision-guided munition systems.
These included the first cruise missile, the first short-range ballistic missile, the first guided surface-to-air missiles, and the first anti-ship missiles.
The V1, which may be seen as the first cruise missile, was used operationally against London and Antwerp. The V-2 ballistic missile was used operationally against London, Antwerp, and other targets. The Rheinbote was fired against Antwerp.
Germany developed a number of surface-to-air missile systems, none of which was used operationally:
As with the surface-to-air missiles above, these were never used operationally:
Anti-ship missiles were used operationally against allied shipping in 1943, notably in the Mediterranean Sea, guided by the Funkgerät FuG 203 Kehl series of MCLOS radio guidance systems aboard the deploying aircraft:
The Mistel composite aircraft configuration was used (with almost no effects) on the front lines both on western and eastern front. This system was composed by a bomber filled with explosive, coupled to a fighter plane: the pilot in the fighter plane flew the two coupled airplanes up to near the target, then he disconnected the aircraft and commanded the bomber to crash onto the target by radio control.