The following is a list of persons from Spanish-speaking countries or of Hispanic descent who have travelled into space, sorted by date of first flight.

The first country listed is that of citizenship; the second, if any, is that of the Spanish-speaking country of birth or ancestry.

Orbital

#	Image	Name Birth date	Country	Comment	Missions (Launch date)
1		Arnaldo Tamayo Méndez January 29, 1942	Cuba	First person from Latin America to fly in space. First person of African descent in space. First Cuban in space.	Soyuz 38 (September 18, 1980)
2		Rodolfo Neri Vela February 19, 1952	Mexico	First Mexican in space.	STS-61-B (November 26, 1985)
3		Franklin Chang-Diaz April 5, 1950	United States ( Costa Rica)	First Costa Rican astronaut	STS-61-C (January 12, 1986) STS-34 (October 18, 1989) STS-46 (July 31, 1992) STS-60 (February 3, 1994) STS-75 (February 22, 1996) STS-91 (June 2, 1998) STS-111 (June 5, 2002)
4		Sidney M. Gutierrez June 27, 1951	United States ( Mexico)	First U.S.-born Hispanic astronaut	STS-40 (June 5, 1991) STS-59 (April 9, 1994)
5		Ellen Ochoa May 10, 1958	United States ( Mexico)	First female Hispanic astronaut	STS-56 (April 8, 1993) STS-66 (November 3, 1994) STS-96 (May 27, 1999) STS-110 (April 8, 2002)
6		Michael Lopez-Alegria May 30, 1958	United States- Spain[1] ( Spain)	First Spanish-born astronaut	STS-73 (October 20, 1995) STS-92 (October 11, 2000) STS-113 (November 24, 2002) Soyuz TMA-9 (September 18, 2006) Axiom Mission 1 (April 8, 2022)
7		Carlos I. Noriega October 8, 1959	United States ( Peru)	First Peruvian-born astronaut	STS-84 (May 15, 1997) STS-97 (November 30, 2000)
8		Pedro Duque March 14, 1963	Spain	First Spanish astronaut without dual citizenship	STS-95 (October 29, 1998) Soyuz TMA-3/2 (October 18, 2003)
9		John D. Olivas May 25, 1965	United States ( Mexico)		STS-117 (June 8, 2007) STS-128 (August 28, 2009)
10		George D. Zamka	United States ( Colombia)		STS-120 (October 23, 2007) STS-130 (February 8, 2010)
11		Joseph M. Acaba May 17, 1967	United States ( Puerto Rico)	First Puerto Rican astronaut	STS-119 (March 15, 2009) Soyuz TMA-04M (May 15, 2012)[2] Soyuz MS-06 (September 12, 2017)
12		José M. Hernández August 7, 1962	United States ( Mexico)	First migrant farm worker in space.	STS-128 (August 28, 2009)
13		Serena M. Auñón Apr. 9, 1976	United States ( Cuba)		Soyuz MS-09 (June 6, 2018)
14		Francisco Rubio December 11, 1975	United States ( El Salvador)	First salvadoreño astronaut.	Soyuz MS-22 (Sept. 21, 2022)

Suborbital

#	Name Birth date	Country	Comment	Missions (Launch date)
1	Katya Echazarreta June 16, 1995	United States ( Mexico)	Suborbital flight to a height of 106 km	Blue Origin NS-21 (June 4, 2022)

Other Hispanic astronauts

Image	Name Birth date	Country	Comment
	José López Falcón February 8, 1950	Cuba	Backup for Arnaldo Tamayo Mendez on Soyuz 38
	Ricardo Peralta y Fabi	Mexico	Backup for Rodolfo Neri Vela on STS-61-B
	Fernando Caldeiro June 12, 1958	United States ( Argentina)	Died October 3, 2009.