Abilene is the ending point of the Chisholm Trail where the cattle driven from Texas were loaded onto rail cars.
Constitution Hall in Lecompton is the building where the Kansas Territorial Government convened and drafted the pro-slavery Lecompton Constitution of 1857.
Constitution Hall in Topeka is the building where the Kansas Free State Government in the Kansas Territorial era convened and drafted the anti-slavery Topeka Constitution of 1855.
The Sunflower Army Ammunition Plant in De Soto opened in 1942 to manufacture gunpowder and munitions propellants for World War II. The closed plant sits on over 9000 acres (36 km²) of land which was made up of more than 100 farms.
The Dalton Defenders Museum, located in Coffeyville, commemorates the townspeople who died defending the town against the Dalton Gang, who unsuccessfully attempted to rob two Coffeyville banks simultaneously on October 5, 1892.
A replica of Norman Number 1 (supposedly the first oil derrick west of the Mississippi River) and a small museum dedicated to it are located near the chamber of commerce building in Neodesha (located in the eastern end of the town, just before its Main Street merges with U.S. 75).