This is a non-exhaustive list of popular OpenGL programs. Many programs that use OpenGL are games.

Games developed in OpenGL

• Ballenger, a platformer
• Cube 2: Sauerbraten, an open source 3D FPS and also a game engine
• Doom (2016 video game), a FPS
• Minecraft, a famous sandbox video game
• Osu!, famous rhythm game.

Photography and video

• Adobe After Effects, a digital motion graphics and compositing software
• Adobe Photoshop, a popular photo and graphics editing software
• Adobe Premiere Pro, a real-time, timeline based video editing software applications
• ArtRage, traditional media painting software
• Kodi, a cross-platform, open source media center

Modeling and CAD

• 3D Studio Max, modeling, animation and rendering package
• Autodesk AutoCAD, 2D/3D CAD
• Autodesk Maya, modeling, animation, sculpting, and rendering package that uses its own scripting language, MEL
• Blender, 3D CAD, animation and game engine
• Cadence Allegro, Computer-aided design, Electronics
• Houdini, modeling, animation, effects, rendering and compositing package developed by Side Effects Software
• LARSA4D, structural analysis program
• Modo (software), high-end 3D modeling, animation, rigging, rendering and visual effects package
• Rhinoceros, NURBS Modeling for Windows
• SAP2000, structural analysis program
• Scilab, Mathematical tool, clone of MATLAB
• SketchUp, easy to use 3D modeler
• VirtualMec, 3D CAD for the Meccano construction system

Visualization and miscellaneous

• Algodoo, a freeware 2D physics simulator
• Avogadro, a 3D molecular viewer and editor
• BALLView, an interactive 3D visualizations software
• Celestia, a FOSS interactive and extremely modifiable 3D space simulator and planetarium
• Enhanced Machine Controller (EMC2), G-code interpreter for CNC machines
• Google Earth, an extremely high-quality interactive simulation of almost the entire Earth, using data from the ground as well as satellite imagery
• InVesalius, a cross-platform software, visualization medical images and reconstruction
• Mari (software), 3D texturing and painting software
• PyMOL, a 3D molecular viewer
• QuteMol, a 3D molecular renderer
• Really Slick Screensavers, 3D Screensavers
• SpaceEngine, a 3D interactive planetarium program that uses real data and procedural generation to fill in the gaps
• OpenUniverse, a 3D interactive planetarium program originally made by JPL in 1997 under the name "Solar System Simulator", later improved by Raúl Alonso Álvarez and released to the public under the name "OpenUniverse" in 2000
• Stellarium, a high quality planetarium program
• Vectorworks, a cross-platform Mac/Windows 2D and 3D CAD for architectural & landscape design, offers a Renderworks module based on the Maxon CineRender engine
• Virtools, a real-time 3D engine
• Vizard, a platform for building and rendering enterprise and academic virtual reality applications developed by WorldViz