The following is a list of Oricon number-one singles of 2001.
| Issue date | Song | Artist(s) | Ref. |
|---|---|---|---|
| January 1 | "M" | Ayumi Hamasaki | [1] |
| January 8 | |||
| January 15 | "Fragile" | Every Little Thing | |
| January 22 | |||
| January 29 | "Minimoni. Jankenpyon!" | Minimoni | |
| February 5 | |||
| February 12 | "Evolution" | Ayumi Hamasuki | |
| February 19 | "Boku no Senaka ni wa Hane ga Aru" | KinKi Kids | |
| February 26 | "Can You Keep a Secret?" | Hikaru Utada | |
| March 5 | |||
| March 12 | "Baby! Koi ni Knock Out!" | Petitmoni | |
| March 19 | "Never Ever" | Ayumi Hamasaki | |
| March 26 | "ultra soul" | B'z | |
| April 2 | |||
| April 9 | "Ai no bakayaro" | Maki Goto | |
| April 16 | "Ashita ga arusa" | Re:Japan | |
| April 23 | "Pieces of a Dream" | Chemistry | |
| April 30 | "Kimi no tame ni boku ga iru" | Arashi | |
| May 7 | "Global Communications" | Glay | |
| May 14 | "Zero Landmine" | NML | |
| May 21 | |||
| May 28 | "Endless sorrow" | Ayumi Hamasaki | |
| June 4 | "Jonetsu" | KinKi Kids | |
| June 11 | "Message" | Tokio | |
| June 18 | "Point of No Return" | Chemistry | |
| June 25 | |||
| July 2 | "Lifetime Respect" | Dōzan Miki | |
| July 9 | "Agehachō" | Porno Graffitti | |
| July 16 | "Naminori Jonny" | Keisuke Kuwata | |
| July 23 | "UNITE!" | Ayumi Hamasaki | |
| July 30 | "Naminori Jonny" | Keisuke Kuwata | |
| August 6 | "The Peace!" | Morning Musume | |
| August 13 | "Jidai" | Arashi | |
| August 20 | "Gold" | B'z | |
| August 27 | |||
| September 3 | "Yasashii uta" | Mr. Children | |
| September 10 | "Dasenai tegami" | V6 | |
| September 17 | "Spirit dreams inside" | L'Arc-en-Ciel | |
| September 24 | "Mini-Moni Telephone! Rin Rin Rin" | Minimoni | |
| October 1 | "Hitohirano jiyu" | Glay | |
| October 8 | "Dearest" | Ayumi Hamasaki | |
| October 15 | |||
| October 22 | "you go your way" | Chemistry | |
| October 29 | "evergreen" | Hyde | |
| November 5 | "Shiroi koibitotachi" | Keisuke Kuwata | |
| November 12 | "Mr. Moonlight (Ai no Big Band)" | Morning Musume | |
| November 19 | "Youthful Days" | Mr. Children | |
| November 26 | "Hey! Minna genki kai?" | KinKi Kids | |
| December 3 | "Ōjisama to yuki no yoru" | Tanpopo | |
| December 10 | "Traveling" | Hikaru Utada | |
| December 17 | |||
| December 24 | "A Song is Born" | Ayumi Hamasaki and Keiko | |
| December 31 | "Always (A Song For Love)" | J Friends |