These are the RPM magazine Dance number one hits of 2000. The chart ceased publication in November 2000 and the final published chart was November 6, 2000.
| Issue date | Song | Artist | Reference(s) |
|---|---|---|---|
| January 10 | "Sun Is Shining" | Bob Marley vs. Funkstar De Luxe | [1] |
| January 17 | "Better Off Alone" | Alice DeeJay | [2] |
| January 24 | "Get Get Down" | Paul Johnson | [3] |
| January 31 | "Better Off Alone" | Alice DeeJay | [4] |
| February 7 | "Sun Is Shining" | Bob Marley vs. Funkstar De Luxe | [5] |
| February 14 | [6] | ||
| February 21 | "Get Get Down" | Paul Johnson | [7] |
| February 28 | "Better Off Alone" | Alice DeeJay | [8] |
| March 6 | "Don't Call Me Baby" | Madison Avenue | [9] |
| March 13 | "Move Your Body" | Eiffel 65 | [10] |
| March 20 | "Don't Call Me Baby" | Madison Avenue | [11] |
| March 27 | [12] | ||
| April 3 | [13] | ||
| April 10 | "Fly Away (Bye Bye)" | Eyes Cream | [14] |
| April 17 | [15] | ||
| April 24 | [16] | ||
| May 1 | [17] | ||
| May 8 | [18] | ||
| May 15 | "My Feeling" | Junior Jack | [19] |
| May 22 | [20] | ||
| May 29 | [21] | ||
| June 5 | [22] | ||
| June 12 | [23] | ||
| June 19 | [24] | ||
| June 26 | "He Wasn't Man Enough" | Toni Braxton | [25] |
| July 3 | "My Feeling" | Junior Jack | [26] |
| July 10 | "He Wasn't Man Enough" | Toni Braxton | [27] |
| July 17 | [28] | ||
| July 24 | "You See the Trouble with Me" | Black Legend | [29] |
| July 31 | [30] | ||
| August 7 | [31] | ||
| August 14 | [32] | ||
| August 21 | "I Got This Feeling" | Baby Bumps | [33] |
| August 28 | [34] | ||
| September 4 | [35] | ||
| September 11 | "Kernkraft 400" | Zombie Nation | [36] |
| September 18 | [37] | ||
| September 25 | [38] | ||
| October 2 | [39] | ||
| October 9 | "Here Comes the Sunshine" | Love Inc. | |
| October 16 | [40] |