The following is a list of Sites of Special Scientific Interest in the Annandale and Eskdale Area of Search. For other areas, see List of SSSIs by Area of Search.

Bell's Flow
Bigholms Burn
Castle Loch
Dryfe Water
Langholm - Newcastleton Hills
Loch Wood
Lochmaben Lochs
Moffat Hills
Penton Linns
Perchhall Loch
Raeburn Flow
River Esk, Glencartholm
River Tweed
Royal Ordnance Powfoot
Upper Solway Flats and Marshes

v t e SSSIs in the United Kingdom, grouped by Area of Search
England	Avon Bedfordshire Berkshire Buckinghamshire Cambridgeshire Cheshire Cleveland Cornwall County Durham Cumbria Derbyshire Devon Dorset East Riding of Yorkshire East Sussex Essex Gloucestershire Greater London Greater Manchester Hampshire Herefordshire Hertfordshire Isle of Wight Kent Lancashire Leicestershire Lincolnshire Merseyside Norfolk North Yorkshire Northamptonshire Northumberland Nottinghamshire Oxfordshire Rutland Shropshire Somerset South Yorkshire Staffordshire Suffolk Surrey Tyne and Wear Warwickshire West Midlands West Sussex West Yorkshire Wiltshire Worcestershire
Scotland	Angus and Dundee Annandale and Eskdale Badenoch and Strathspey Banff and Buchan Berwickshire and Roxburgh Caithness Clydesdale and South East Glasgow Cumnock and Kyle Dumbarton and North Glasgow Dunfermline and Kirkcaldy East Perth East Ross and Cromarty Edinburgh and West Lothian Falkirk and Clackmannan Gordon and Aberdeen Inverness Islay and Jura Kincardine and Deeside Kintyre Lorne Mid and East Lothian Mid Argyll and Cowal Moray and Nairn Mull, Coll and Tiree Nithsdale North East Fife North Lochaber North West Sutherland North Wester Ross and Cromarty Orkney Renfrew and Cunninghame Rum and the Small Isles Shetland Skye and Lochalsh South East Sutherland South Lochaber South Perth South Wester Ross and Cromarty Stirling Tweeddale and Ettrick and Lauderdale West Perth Western Isles North Western Isles South Wigtown and Stewartry
Wales	Brecknock Carmarthen & Dinefwr Ceredigion Clwyd East Gwynedd Gwent Mid & South Glamorgan Montgomery Preseli & South Pembrokeshire Radnor West Glamorgan West Gwynedd
Northern Ireland	County Antrim County Armagh County Down County Fermanagh County Londonderry County Tyrone

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