Trans-Texas Airways (TTa) and successor Texas International Airlines flew to the following cities in 1949 through 1982. This information is taken from Trans-Texas Airways and Texas International Airlines timetables referenced below.

Alabama

• Mobile - Mobile Regional Airport (MOB)

Arizona

• Phoenix - Sky Harbor International Airport (PHX)
• Tucson - Tucson International Airport (TUS)

Arkansas

• Camden - Harrell Field (CDH)
• El Dorado - South Arkansas Regional Airport at Goodwin Field (ELD)
• Helena - Thompson-Robbins Airport (HEE)
• Hot Springs - Memorial Field Airport (HOT)
• Jonesboro - Jonesboro Municipal Airport (JBR)
• Little Rock - Little Rock National Airport (LIT)
• Magnolia - Magnolia Municipal Airport (AGO)
• Pine Bluff - Grider Field (PBF)
• Stuttgart - Stuttgart Municipal Airport (SGT)
• Texarkana - Texarkana Regional Airport (TXK)
• West Helena - served via Helena

California

• Los Angeles - Los Angeles International Airport (LAX)
• Ontario - Ontario International Airport(KONT)

Colorado

• Colorado Springs - Colorado Springs Municipal Airport (COS)
• Denver - Stapleton International Airport (DEN)

Connecticut

• Hartford - Bradley International Airport (BDL) - also serves Springfield, MA.

Florida

• Fort Lauderdale - Fort Lauderdale International Airport (FLL)
• Pensacola - Pensacola International Airport (PNS)

Louisiana

• Alexandria - Esler Regional Airport (ESF)
• Baton Rouge - Baton Rouge Metropolitan Airport (BTR)
• Fort Polk - served via Beauregard Regional Airport (DRI) in De Ridder, LA
• Lafayette - Lafayette Regional Airport (LFT)
• Lake Charles - Lake Charles Regional Airport (LCH)
• Monroe - Monroe Regional Airport (MLU)
• Morgan City - served via Harry P. Williams Airport (PTN) in Patterson, LA
• New Orleans - Louis Armstrong International Airport (MSY)
• Shreveport - Shreveport Regional Airport (SHV)

Maryland

• Baltimore - Baltimore/Washington International Airport (BWI)

Minnesota

• Minneapolis/St. Paul - Minneapolis/St. Paul International Airport (MSP)

Mississippi

• Jackson - Jackson-Evers International Airport (JAN)
• Natchez - Natchez-Adams County Airport (HEZ)

Missouri

• Kansas City - Kansas City International Airport (MCI)
• St. Louis - Lambert-St. Louis International Airport (STL)

Nebraska

• Omaha - Eppley Airfield (OMA)

Nevada

• Las Vegas - McCarran International Airport (LAS)

New Mexico

• Albuquerque - Albuquerque International Sunport (ABQ)
• Carlsbad - Cavern City Air Terminal (CNM)
• Clovis - Clovis Municipal Airport (CVN)
• Hobbs - Lea County Regional Airport (HOB)
• Las Cruces - served via El Paso International Airport (ELP) in El Paso, Texas
• Roswell - Roswell International Air Center (ROW)
• Santa Fe - Santa Fe Municipal Airport (SAF)

Ohio

• Cleveland - Hopkins International Airport (CLE)

Oklahoma

• Oklahoma City - Will Rogers Airport (OKC)
• Tulsa - Tulsa International Airport (TUL)
• Ardmore - Ardmore Airpark (ARD)

Tennessee

• Memphis - Memphis International Airport (MEM)

Texas

• Abilene - Abilene Regional Airport (ABI)
• Alice - Alice Airport (ALI)
• Alpine - served via Marfa
• Amarillo - Rick Husband Amarillo International Airport (AMA)
• Austin - Robert Mueller Airport, now closed (AUS)
• Beaumont/Port Arthur - Southeast Texas Regional Airport (BPT)
• Beeville - Chase Field
• Big Spring - Big Spring McMahon-Wrinkle Airport (BPG)
• Brady - Curtis Field (BBD)
• Bryan - served via College Station
• Brownsville - Brownsville International Airport (BRO)
• Brownwood - Brownwood Regional Airport (BWD)
• Carrizo Springs - Dimmit County Airport (CZT)
• Coleman - Coleman Municipal Airport (COM)
• College Station - Easterwood Airfield (CLL)
• Corpus Christi - Corpus Christi International Airport (CRP)
• Crystal Springs - served via Carrizo Springs
• Dallas/Fort Worth – Dallas/Fort Worth International Airport (DFW) (Hub)
  • Also previously served were Dallas Love Field (DAL) (Hub) and now closed Greater Southwest International Airport (GSW). The airline moved its flights from Love Field to Dallas/Ft. Worth Intl. Airport when DFW opened in 1974.
• Del Rio - Val Verde County Airport (DRT)
• Eagle Pass - Maverick County Airport (5T9)
• El Paso – El Paso International Airport (ELP)
• Fort Stockton - Gibbs Field (FST)
• Galveston - Scholes International Airport at Galveston (GLS)
• Harlingen - Valley International Airport (HRL)
• Houston – George Bush Intercontinental Airport (IAH) (Hub)
  • Also previously served was William P. Hobby Airport (HOU) (Hub). The airline moved its flights from Hobby to Intercontinental when IAH opened in 1969. Texas International continued to operate a maintenance base at HOU which was subsequently used by Continental Airlines following the merger of the two air carriers.
• Kerrville - Kerrville Municipal Airport (ERV)
• Laredo - Laredo International Airport (LRD)
• Longview - East Texas Regional Airport (GGG)
• Lubbock - Lubbock Preston Smith International Airport (LBB)
• Lufkin - Angelina County Airport (LFK)
• Marfa - Marfa Army Air Field (MRF)
• Marshall - Harrison County Airport (Texas) (ASL)
• McAllen – McAllen-Miller International Airport (MFE)
• McCamey - Upton County Airport (E48)
• Midland - Midland International Airport (MAF) - also serves Odessa, TX
• Nacogdoches - Del Rentzel Field (currently A.L. Mangham Jr. Regional Airport) (OCH)
• Palestine - Palestine Municipal Airport (PSN)
• Pecos - Pecos Municipal Airport (PEQ)
• San Angelo - San Angelo Regional Airport (SJT)
• San Antonio – San Antonio International Airport (SAT)
• Temple - Draughon-Miller Central Texas Regional Airport (TPL)
• Tyler - Tyler Pounds Regional Airport (TYR)
• Uvalde - Garner Field (UVA)
• Victoria - Victoria Regional Airport (VCT)
• Waco - Waco Regional Airport (ACT)
• Wichita Falls - Wichita Falls Municipal Airport (SPS)

Utah

• Salt Lake City - Salt Lake City International Airport (SLC)

Virginia

• Washington, D.C. - Reagan National Airport (DCA)

Wisconsin

• Milwaukee - General Mitchell International Airport (MKE)

Mexico

• Cancun (CUN)
• Cozumel (CZM)
• Ciudad Juarez - served via El Paso International Airport (ELP) in El Paso, Texas
• Guadalajara (GDL)
• Manzanillo (ZLO)
• Mérida (MID)
• Mexico City - Benito Juarez International Airport (MEX)
• Monterrey (MTY)
• Puerto Vallarta (PVR)
• Tampico (TAM)
• Veracruz (VER)
• Zihuatanejo - Ixtapa-Zihuatanejo International Airport (ZIH) - route inherited by Continental and as of 2018 United Express