These hits topped the Ultratop 50 in 2008.[1]
| Issue Date | Artist | Song |
| January 5 | Rihanna | Don't Stop the Music |
| January 12 | ||
| January 19 | ||
| January 26 | ||
| February 2 | ||
| February 9 | Leona Lewis | Bleeding Love |
| February 16 | ||
| February 23 | ||
| March 1 | ||
| March 8 | ||
| March 15 | ||
| March 22 | ||
| March 29 | Ishtar | O julissi 1 |
| April 5 | ||
| April 12 | Christoff | Een ster (A Star) |
| April 19 | Laura Lynn & Frans Bauer | Al duurt de nacht tot morgenvroeg |
| April 26 | Madonna featuring Justin Timberlake and Timbaland | 4Minutes |
| May 3 | ||
| May 10 | ||
| May 17 | ||
| May 24 | ||
| May 31 | ||
| June 7 | Estelle feat Kanye West | American Boy |
| June 14 | ||
| June 21 | Laurent Wolf | No Stress |
| June 28 | Amy Macdonald | This Is the Life |
| July 5 | ||
| July 12 | ||
| July 19 | ||
| July 26 | ||
| August 2 | ||
| August 9 | ||
| August 16 | ||
| August 23 | ||
| August 30 | ||
| September 6 | ||
| September 13 | Katy Perry | I Kissed a Girl |
| September 20 | ||
| September 27 | ||
| October 4 | ||
| October 11 | Rihanna | Disturbia |
| October 18 | Katy Perry | I Kissed a Girl |
| October 25 | Milow | Ayo Technology |
| November 1 | ||
| November 8 | Guru Josh Project | Infinity 2008 |
| November 15 | ||
| November 22 | ||
| November 29 | ||
| December 6 | ||
| December 13 | ||
| December 20 | Britney Spears | Womanizer |
| December 27 | Tom Helsen & Geike Arnaert | Home |