| No. | City | Province | 2010 Census | 2001 Census | 1990 Census |
|---|---|---|---|---|---|
| 1 | Guayaquil | Guayas | 2,278,691 | 1,985,379 | 1,508,444 |
| 2 | Quito | Pichincha | 1,607,734 | 1,399,378 | 1,100,847 |
| 3 | Cuenca | Azuay | 329,928 | 277,374 | 194,981 |
| 4 | Santo Domingo | Santo Domingo | 270,875 | 238,827 | 114,422 |
| 5 | Machala | El Oro | 231,260 | 204,578 | 144,197 |
| 6 | Durán | Guayas | 230,839 | 174,531 | 82,359 |
| 7 | Manta | Manabí | 217,553 | 183,105 | 125,505 |
| 8 | Portoviejo | Manabí | 206,682 | 171,847 | 132,937 |
| 9 | Ibarra | Imbabura | 181,175 | 153,256 | |
| 10 | Quevedo | Los Ríos | 173,585 | 139,790 | |
| 11 | Loja | Loja | 170,280 | 118,532 | 94,300 |
| 12 | Ambato | Tungurahua | 165,185 | 154,095 | 124,166 |
| 13 | Esmeraldas | Esmeraldas | 161,868 | 157,792 | |
| 14 | Riobamba | Chimborazo | 156,723 | 193,315 | |
| 15 | Milagro | Guayas | 133,508 | ||
| 16 | Latacunga | Cotopaxi | 98,355 | ||
| 17 | La Libertad | Santa Elena | 95,942 | ||
| 18 | Babahoyo | Los Ríos | 90,191 |
