Route 108 or Highway 108 can refer to multiple roads:

Canada

• New Brunswick Route 108
• Ontario Highway 108
• Prince Edward Island Route 108
• Quebec Route 108

China

• China National Highway 108

Costa Rica

• National Route 108

India

• National Highway 108 (India)

Japan

• Route 108 (Japan)

Philippines

• N108 highway (Philippines)

United States

• Alabama State Route 108
• Arkansas Highway 108
• California State Route 108
• Connecticut Route 108
• Florida State Road 108 (pre-1945) (former)
• Georgia State Route 108
• Illinois Route 108
• Iowa Highway 108 (former)
• K-108 (Kansas highway) (former)
• Kentucky Route 108
• Louisiana Highway 108
• Maine State Route 108
• Maryland Route 108
  • Maryland Route 108A
  • Maryland Route 108H
• Massachusetts Route 108
• M-108 (Michigan highway) (former)
• Minnesota State Highway 108
• Missouri Route 108
• Nebraska Highway 108 (former)
• New Hampshire Route 108
• County Route 108 (Bergen County, New Jersey)
• New Mexico State Road 108
• New York State Route 108
  • County Route 108 (Cayuga County, New York)
  • County Route 108A (Cortland County, New York)
    • County Route 108B (Cortland County, New York)
  • County Route 108 (Fulton County, New York)
  • County Route 108 (Montgomery County, New York)
  • County Route 108 (Niagara County, New York)
  • County Route 108 (Onondaga County, New York)
  • County Route 108 (Rockland County, New York)
  • County Route 108 (Saratoga County, New York)
  • County Route 108 (Seneca County, New York)
  • County Route 108 (Suffolk County, New York)
  • County Route 108 (Sullivan County, New York)
  • County Route 108 (Wayne County, New York)
  • County Route 108 (Westchester County, New York)
• North Carolina Highway 108
• Ohio State Route 108
• Oklahoma State Highway 108
• Pennsylvania Route 108
• Rhode Island Route 108
• Tennessee State Route 108
• Texas State Highway 108
  • Texas State Highway Loop 108
  • Texas State Highway Spur 108
    • Texas State Highway Spur 108 (1940–1942) (former)
  • Farm to Market Road 108
• Utah State Route 108
• Vermont Route 108
• Virginia State Route 108
  • Virginia State Route 108 (1923-1928) (former)
  • Virginia State Route 108 (1928-1932) (former)
• Washington State Route 108
• Wisconsin Highway 108

Territories

• Puerto Rico Highway 108
• U.S. Virgin Islands Highway 108