Route 109 or Highway 109 can refer to multiple roads:
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N109 highway (Philippines)
U.S. Route 109 (former)
Alabama State Route 109
Arkansas Highway 109
California State Route 109
Colorado State Highway 109
Connecticut Route 109
Florida State Road 109
Georgia State Route 109
Illinois Route 109
Indiana State Road 109
Iowa Highway 109
Kentucky Route 109
Louisiana Highway 109
Maine State Route 109
Maryland Route 109
Massachusetts Route 109
M-109 (Michigan highway)
Minnesota State Highway 109
Missouri Route 109
Nebraska Highway 109
Nebraska State Spur 109 (former)
New Hampshire Route 109
New Jersey Route 109
New Mexico State Road 109
New York State Route 109
County Route 109 (Cortland County, New York)
County Route 109 (Erie County, New York)
County Route 109 (Fulton County, New York) County Route 109 (Madison County, New York) County Route 109 (Montgomery County, New York) County Route 109 (Onondaga County, New York)
County Route 109 (Rockland County, New York)
County Route 109 (Sullivan County, New York) County Route 109 (Tompkins County, New York)
North Carolina Highway 109
North Carolina Highway 109A (Thomasville) (former) North Carolina Highway 109A (Troy) (former)
Ohio State Route 109
Oklahoma State Highway 109
South Carolina Highway 109
South Dakota Highway 109
Tennessee State Route 109
Texas State Highway 109 (former)
Utah State Route 109
Vermont Route 109
Virginia State Route 109
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Virginia State Route 109 (1923-1928) (former) Virginia State Route 109 (1928-1933) (former) Virginia State Route 109 (1933-1946) (former)
Washington State Route 109
Wisconsin Highway 109
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